0:00

That's ILA interstitial lung abnormality.

0:03

The progressive pulmonary fibrosis idea is

0:05

very similar to ILA.

0:07

So progressive pulmonary fibrosis is, are gonna be cases

0:11

of pulmonary fibrosis

0:12

that are not idiopathic pulmonary fibrosis.

0:15

So I, as I alluded to

0:17

before, most clinics are gonna have a big

0:22

proportion of their, their interstitial lung disease cases

0:25

be IPF and so almost all cases of ipf

0:29

or maybe it's better, just better say by definition,

0:31

these IPF cases are all gonna get worse.

0:33

And so we know these IPF cases are getting worse,

0:36

but other types of pulmonary fibrosis, some

0:38

of them actually don't get worse.

0:40

The ones that do get worse, these are gonna be patients

0:43

who we, we invoke this idea

0:45

of progressive pulmonary fibrosis.

0:47

And so how do you figure this out

0:49

and how do you make sure sort of define

0:51

that patient is getting worse?

0:52

Well, it's gonna be a combination of clinical symptoms,

0:57

functional abnormalities and radiologic

0:59

progression within the past year.

1:01

And so these patients may benefit from antifibrotic therapy

1:06

as do patients with idiopathic pulmonary fibrosis.

1:08

Again, this is not a diagnosis.

1:10

PPF is not a diagnosis, it's an idea.

1:12

It's sort of taking these non IPF subset of patients here,

1:15

right, saying Oh, these are non IP patients.

1:17

I'm saying, alright, well these subset that are progressing,

1:20

these patients may benefit from this additional antifibrotic

1:24

therapy because we have data to back that up.

1:26

That is the purpose of progressive pulmonary fibrosis.

1:29

So I'm sure you guys see some of the corollaries

1:30

between progressive pulmonary fibrosis

1:32

and the, the idea of interstitial lung abnormalities.

1:37

So again, any type

1:38

of pulmonary fibrosis can be a progressive pulmonary

1:41

fibrosis except I-P-F-I-P-F

1:43

by definition is gonna be getting worse.