Upcoming Events
Log In
Pricing
Free Trial

Case: Normal Distribution of PSMA Tracer

HIDE
PrevNext

0:00

In this case, this 73-year-old man was image

0:05

with PSMA to identify areas of disease

0:11

as he presented with biochemical recurrence.

0:14

But I wanna show you the normal distribution of this tracer.

0:20

The PSMA expression

0:23

is found in the normal salivary

0:26

and lacrimal glands as we can see here,

0:29

and it's common to see very intense uptake.

0:34

It is also seen in many cases in breast,

0:38

and even though this would essentially be used in

0:43

male patients only patients can have gynecomastia

0:48

and uh, show uptake in the breast parenchyma.

0:53

Also, the trace bounds to the

0:57

tubules in the kidneys, as well as in the small bowel,

1:02

which is more intensely in the duodenum, in the epithelial

1:07

of the duodenum in the brush border.

1:09

Also, we see an intense uptake diffusely in the liver

1:13

because there's uptake in the cup for cells.

1:16

It is common to see tracer uptake in the ureters

1:20

as the tracer is excreted

1:22

and also intense uptake in the bladder from

1:26

a concentrated tracer.

1:28

In this case, we see that changing a little bit.

1:31

The contrast, the bladder is full

1:35

and there's higher concentration in the dependent portions

1:38

of the bladder from a mix of excreted tracer

1:42

and probably already existing urine

1:46

because many

1:47

of these patients may have outlet obstruction to some degree.

1:53

Normally, if you don't have disease in the prostate, uh,

1:58

you should expect low level of tracer uptake.

2:02

As you can see here, in this case, this patient

2:05

has fiducial markers, uh,

2:07

from a previously treated prostate,

2:09

and we see that the uptake is low and is diffused,

2:12

and there's no areas of increased uptake.

2:16

The bone marrow should have low uptake,

2:20

and this will be helpful in identifying osseous lesions

2:24

that are so common in patients with prostate cancer.

2:28

Similarly to Dotatate, we can also identify

2:33

low level uptake in both the stalet ganglion

2:37

and the celiac ganglion, as well

2:40

as sometimes in the sacral ganglion.

Report

Faculty

Elisa Franquet Elia, MD

Assistant Professor of Radiology

UMass Chan Medical School

Tags

Prostate/seminal vesicles

PET/CT PSMA

PET

Oncologic Imaging

Nuclear Medicine

Neoplastic

Genitourinary (GU)