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FDG: Patterns of Bone Marrow Uptake and the Effects of Bone Marrow Disease

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0:01

This is an FEG PET CT perform on a 25-year-old male,

0:06

had presented with back pain

0:09

and had lumbar spine MRI done that showed abnormal

0:14

bone marrow uptake and this was concerning for, uh, lymphoma

0:19

and therefore he underwent an FDG pity for staging

0:25

as opposed to the other cases we just discussed.

0:30

There is also in this case,

0:32

abnormal tracer uptake in the bone marrow of the axial

0:35

and appendicular skeleton, but in this case is multifocal

0:38

heterogeneous and this is a case

0:43

of bone marrow disease.

0:46

When we look closer, look at the axial use,

0:51

uh, of the pit, we see that all these areas

0:54

of intense focal uptake

0:56

and don't actually have a correlation on the CT

1:00

because these are not osseous lesions,

1:02

but lesions within the bone marrow compartment.

1:06

And that's an important distinction to make.

1:09

But distinguishing what's an abnormal bone marrow appearance

1:14

from something that may be a physiological response.

1:18

In the case of bone marrow stimulators is important

1:22

for an appropriate diagnosis.

1:25

In this case, there are no correlating lesions.

1:28

It could be that all the areas of uptake may correspond

1:32

with also changes in the bone.

1:35

In this case, uh, we don't have that, which tells us

1:39

that this is just bone marrow disease.

1:43

Another thing that we have in this patient was, uh,

1:47

abnormal asplenic uptake, uh,

1:49

shows us increased uptake compared to the liver

1:53

and in this case, the size was normal.

1:56

I had mentioned earlier that the size might,

1:59

might help you distinguish.

2:01

However, the combination of a Apache

2:04

or heterogeneous one marrow with an abnormal spleen now, uh,

2:09

raises concern for involvement of the spleen

2:13

or alternatively a physiological response to disease.

2:17

We will probably don't know the exact answer, uh,

2:22

without a biopsy, but this is something we should include in

2:25

our report to make sure

2:28

that the subsequent pets address the resolution

2:32

of this finding or not.

Report

Faculty

Elisa Franquet Elia, MD

Assistant Professor of Radiology

UMass Chan Medical School

Tags

Response and assessment

PET/CT FDG

PET

Oncologic Imaging

Nuclear Medicine

Neoplastic

General Oncologic Imaging Concepts