Upcoming Events
Log In
Pricing
Free Trial

Introduction to DOTATATE

HIDE
PrevNext

0:00

In this video, we are going to discuss a different tracer.

0:04

In this case it's Dotatate.

0:07

We're gonna talk about some basic concepts

0:10

so you can understand this, uh, tracer

0:13

and how it can help you.

0:15

So, metastatin is an important hormone that, uh, regulates,

0:20

uh, neuro transmission cell proliferation

0:23

and the release of other hormones.

0:25

And it's, uh, found physiologically in the body.

0:29

And we have many organs where, uh, Soto acts,

0:33

including the hypothalamus, the pancreas, the small bowel

0:38

and central, uh, nerve system.

0:42

Although that is not seen to a, a great degree on, on pet,

0:47

the other organs will become important.

0:51

There are some sine receptors in many tissues of the body.

0:55

And these receptors will also be expressed in narrow

0:59

endocrine tumors, which is the reason why we

1:03

use this tracer.

1:04

For the evaluation of this type of malignancy.

1:07

We have several available.

1:10

The most commonly used is the first one, dotatate.

1:13

These tracer are synthetic somatostatin analogs, and

1:17

therefore they will bind

1:19

to the somatostatin receptors the same way

1:21

somatostatin would.

1:23

There are five types of receptors named 1, 2, 3, 4, 5,

1:28

and the number two is the most commonly found in

1:31

neuroendocrine tumors.

1:33

And this is important to know

1:36

because not all the malignancies may express number

1:41

two, and the different tracers may have different

1:46

sensitivity to the different types of receptor.

1:50

But I would say that

1:51

because the most commonly found is number two,

1:55

dotatate is a great tracer to evaluate these malignancies.

1:59

So when do we use dotatate?

2:02

As I said, for neuroendocrine tumors,

2:04

and we can use it both for these

2:08

gastroenter pancreatic net tumors,

2:11

where dotatate has a 93% sensitivity

2:15

and 95% specificity.

2:18

But also we could use it for neuroendocrine tumors

2:21

of the lung, like a carcinoid, when sometimes we found

2:26

that there is metastasis proven from a neuroendocrine tumor,

2:30

but we don't have a primary primary.

2:32

This PET C will be very helpful in trying to

2:35

identify the primary lesion to be able to establish

2:40

and plan a treatment strategy.

2:43

It also helps with, uh, tumor grading and characterization,

2:47

and, uh, we'll cover that in a second.

2:50

We can use the same tracer to follow up after therapy,

2:55

and it will become important in patients when

2:59

Several, uh, lines of treatment have failed.

3:02

They could be treated with radioligand therapy,

3:07

which is essentially dotatate, that instead of being labeled

3:12

to, uh, gallium 68 will be labeled

3:16

to a beta emitter for treatment.

Report

Faculty

Elisa Franquet Elia, MD

Assistant Professor of Radiology

UMass Chan Medical School

Tags

Response and assessment

PET/CT DOTATATE

PET

Other Systems

Oncologic Imaging

Nuclear Medicine

Neuroendocrine

Neoplastic

General Oncologic Imaging Concepts