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Commonly Used Positron-emitting Radionuclides

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We have many radionuclides that we use in the clinic.

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I have put in bold the most commonly used F 18

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copper and gallium.

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And uh, we have others,

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but these are the three most used in oncology.

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These cleide can be labeled

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to different particles and molecules.

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And with that combination we will be able

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to image the specific physiology we're interested in.

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For example, in the first case, we have fluro deoxy glucose,

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or commonly known as FDG.

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And this tracer will allow us

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to study the glucose consumption in the body,

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both physiologically in, in areas of of disease.

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Then we have dotatate or DOTA compounds.

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It's a somatostatin receptor analog that would allow us

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to see neuroendocrine tumors

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as they express these receptors on their surface.

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Then we have others that are used more in prostate cancer,

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lovine, or commonly known as axin.

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And the new PSMA, which is a transmembrane glycoprotein

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that is expressed in the prostate cancer cells.

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Flora is an example of a labeled estradiol,

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um, that allows us to see disease that expresses estrogen,

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which happens in breast cancer.

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And then we have fpi, which has not made it to the US yet

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and is in research phase.

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FPI stands for fibroblast activation protein inhibitor.

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These will allow us to see the stromal component

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of malignancies or inflammation.

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It can be used in many settings.

Report

Faculty

Elisa Franquet Elia, MD

Assistant Professor of Radiology

UMass Chan Medical School

Tags

Response and assessment

PET/CT FDG

PET

Oncologic Imaging

Nuclear Medicine

Neoplastic

General Oncologic Imaging Concepts