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On-demand course library with video lectures, expert case reviews, and more
Multispecialty PlansUP TO 25% OFF
Fellowship Certificate™ Programs
20% OFFPractice-focused training programs designed to help you gain experience in a specific subspecialty area.
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UP TO 30% OFFUnlock access to our full Course Library and all self-paced Fellowships.
Continuing Medical Education (State CME)
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Dr. Resnick's MSK Conference
Learn directly from the MSK Master himself.
Lower Extremities MRI Conference
Musculoskeletal Imaging
Emergency Imaging
Emergency GI & Abdominal Radiology FellowshipNEW!
PET Imaging
Pediatric Imaging
For Training Programs
Supplement your training program with case-based learning for residents, registrars, fellows, and more.
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1 topic
8 topics, 31 min. of video
8 topics, 1 hr. 34 min. of video
8 topics, 48 min. of video
8 topics, 37 min. of video
8 topics, 26 min. of video
8 topics, 17 min. of video
8 topics, 1 hr. 24 min. of video
8 topics, 18 min. of video
8 topics, 23 min. of video
8 topics, 1 hr. 25 min. of video
0:00
So the first case that we had was a patient that had pulsatile tinnitus.
0:05
And this was a patient that ended up having multiple gloma tumors.
0:10
So I have to remember exactly where they all were when we first did it. But um,
0:15
yeah, here on this one, um,
0:16
on the left hand side we can see this large gloma tumor and it's actually,
0:20
it's narrowing that int uh, an, uh, excuse me,
0:24
external and internal carotid arteries.
0:26
So technically we're not supposed to use the term GLS tumors anymore.
0:29
People like to use the term paragangliomas. So in the old days,
0:33
I shouldn't say old days, maybe like, you know,
0:35
a few months ago I would call that a GLS Vali. Um,
0:38
but now we're supposed to say paraganglioma vagal type.
0:42
So that's one gloma tumor or paraganglioma. Then we have another,
0:47
uh, paraganglioma that's located here at the jugular. Raven.
0:51
Let me see if I can see that on the T two weighted images. Yeah,
0:54
we can see that right here. You can just follow my hashtag all the way up.
0:59
And that's a paraganglioma that's involved in the jugular foramen.
1:04
And then there's another GLS tumor right here. And this is actually, uh,
1:08
displacing the internal and the external carotid arteries. That would be a, uh,
1:12
GLS tumor, uh, uh, carotid body type.
1:15
And there's another gloma tumor right here, which is, uh, again,
1:19
arising more superiorly and anteriorly displaced in the carotid artery.
1:23
So given the location, that would be a vali as well too.
1:26
So this would be four paragangliomas and multiple paragangliomas.
1:30
So when you see something like this, you have to think of, um,
1:33
some type of familial type of, uh,
1:38
paragangliomas. Um, and there's the deficiency in the succinate dehydrogenase,
1:43
uh, gene, which is, has been associated with multiple paragangliomas.
1:48
Uh, so I can stop there and see if you have any questions for that,
1:51
for this case.
1:54
Not in the E, but I just, you know, expect, eh,
1:58
i I do not expect so many of them can in same patient.
2:03
Well, yesterday I was at tumor. You know, when I go to tumor boards,
2:06
I actually see the patients.
2:08
And so yesterday they showed me a case and the patient wasn't there.
2:12
But this one, they just showed me the films,
2:14
but she actually had multiple paragangliomas and they were actually metastatic.
2:19
And, uh, they were, uh, she actually underwent an octreotide scan.
2:22
Unfortunately, I don't have the disc for that. Um, but um,
2:27
I would like to, I I,
2:28
the octreotide scan was actually very helpful because not only did it the,
2:32
they literally the gloma tumors lit up, but, um, uh,
2:37
they were also, um, showed metastases to the liver.
2:40
So it was actually a malignant form of,
2:45
of metastatic paraganglioma. So it's actually metastatic paragangliomas.
2:50
Oh, you can really meta metastasis I thought is a bit 91.
2:56
Yeah, yeah. Um, yeah, it's, there is that form, which is very unusual
3:02
Because I used to think that if we have the right caric body para can,
3:06
I need to look hard for the left caric body.
3:10
I never expect it occur in other places like Nicum,
3:15
uh, the car. So it's quite new to me.
3:20
Yeah, well teach so.
Interactive Transcript
0:00
So the first case that we had was a patient that had pulsatile tinnitus.
0:05
And this was a patient that ended up having multiple gloma tumors.
0:10
So I have to remember exactly where they all were when we first did it. But um,
0:15
yeah, here on this one, um,
0:16
on the left hand side we can see this large gloma tumor and it's actually,
0:20
it's narrowing that int uh, an, uh, excuse me,
0:24
external and internal carotid arteries.
0:26
So technically we're not supposed to use the term GLS tumors anymore.
0:29
People like to use the term paragangliomas. So in the old days,
0:33
I shouldn't say old days, maybe like, you know,
0:35
a few months ago I would call that a GLS Vali. Um,
0:38
but now we're supposed to say paraganglioma vagal type.
0:42
So that's one gloma tumor or paraganglioma. Then we have another,
0:47
uh, paraganglioma that's located here at the jugular. Raven.
0:51
Let me see if I can see that on the T two weighted images. Yeah,
0:54
we can see that right here. You can just follow my hashtag all the way up.
0:59
And that's a paraganglioma that's involved in the jugular foramen.
1:04
And then there's another GLS tumor right here. And this is actually, uh,
1:08
displacing the internal and the external carotid arteries. That would be a, uh,
1:12
GLS tumor, uh, uh, carotid body type.
1:15
And there's another gloma tumor right here, which is, uh, again,
1:19
arising more superiorly and anteriorly displaced in the carotid artery.
1:23
So given the location, that would be a vali as well too.
1:26
So this would be four paragangliomas and multiple paragangliomas.
1:30
So when you see something like this, you have to think of, um,
1:33
some type of familial type of, uh,
1:38
paragangliomas. Um, and there's the deficiency in the succinate dehydrogenase,
1:43
uh, gene, which is, has been associated with multiple paragangliomas.
1:48
Uh, so I can stop there and see if you have any questions for that,
1:51
for this case.
1:54
Not in the E, but I just, you know, expect, eh,
1:58
i I do not expect so many of them can in same patient.
2:03
Well, yesterday I was at tumor. You know, when I go to tumor boards,
2:06
I actually see the patients.
2:08
And so yesterday they showed me a case and the patient wasn't there.
2:12
But this one, they just showed me the films,
2:14
but she actually had multiple paragangliomas and they were actually metastatic.
2:19
And, uh, they were, uh, she actually underwent an octreotide scan.
2:22
Unfortunately, I don't have the disc for that. Um, but um,
2:27
I would like to, I I,
2:28
the octreotide scan was actually very helpful because not only did it the,
2:32
they literally the gloma tumors lit up, but, um, uh,
2:37
they were also, um, showed metastases to the liver.
2:40
So it was actually a malignant form of,
2:45
of metastatic paraganglioma. So it's actually metastatic paragangliomas.
2:50
Oh, you can really meta metastasis I thought is a bit 91.
2:56
Yeah, yeah. Um, yeah, it's, there is that form, which is very unusual
3:02
Because I used to think that if we have the right caric body para can,
3:06
I need to look hard for the left caric body.
3:10
I never expect it occur in other places like Nicum,
3:15
uh, the car. So it's quite new to me.
3:20
Yeah, well teach so.
Report
Patient History
Pulsatile neck mass.
Findings
Pre- and postcontrast MR was performed from the skull base to the thoracic inlet.
There is a 6cm left carotid sheath mass which is posterior to the left carotid bifurcation and displaces the left ICA anteriorly. The mass is hypervascular, contains multiple flow voids and partially surrounds the left ICA. The mass is separate from the left jugular foramen. The findings are most compatible with a left glomus vagale tumor.
There is a second 2cm hypervascular mass centered to the left jugular foramen occluding the left jugular vein, most compatible with a left glomus jugulare tumor.
There is a third hypervascular 15mm mass which contains multiple flow voids located in the right carotid bifurcation splaying the right ICA and ECA compatible with a right carotid body tumor.
There is a fourth 2cm hypervascular mass at the C1 level in the right carotid space which anteriorly displaces the right ICA. This mass also contains multiple flow voids and partially surrounds the right internal carotid artery. These findings are consistent with a glomus vagale tumor.
There is prominent adenoidal tissue in the nasopharynx which is normal for age. There is also prominence of the palatine tonsils which is also normal for age. No evidence of aggressive lesions is identified involving the floor of mouth or tongue base. The larynx and hypopharynx appear within normal limits without evidence of displaced vocal cord.
The thyroid gland appears to be within normal limits.
Conclusions
1. Multiple paragangliomas involving the neck which include glomus vagale (x2), carotid body tumor and glomus jugulare tumor. Multiple glomus tumors raise the possibility of syndromic causes which includes multiple endocrine neoplasia syndrome and hereditary forms of paraganglioma (paraganglioma syndrome).
2. No obvious evidence of thyroid masses to suggest presence of medullary carcinoma which must be considered in a patient with multiple paragangliomas.
Case Discussion
Faculty
David M Yousem, MD, MBA
Professor of Radiology, Vice Chairman and Associate Dean
Johns Hopkins University
Suresh K Mukherji, MD, FACR, MBA
Clinical Professor, University of Illinois & Rutgers University. Faculty, Michigan State University. Director Head & Neck Radiology, ProScan Imaging
Tags
Neuroradiology
MRI
Head and Neck
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