0:00

Adult tumors.

0:01

I'm just gonna show you some

0:02

of interesting molecularly conjoined, uh, tumor types.

0:06

One is this. So meningioma

0:08

and heman cytoma,

0:10

back in the day when molecular genetics was not the,

0:13

not a thing in terms of our daily conversation, I used

0:16

to think that meningiomas and heman cytomas were related

0:21

and just that the heman of cytomas were much more aggressive

0:25

and angrier looking and destroying the bone.

0:28

And it turns out that, uh, molecular genetics have proven

0:31

that these two tumors are not related at all.

0:36

But it turns out that solitary fibrous tumor,

0:39

which is a pretty rare extra axial tumor that we see,

0:42

but elsewhere in the body too, is intimately associated

0:46

with he angio cytoma,

0:50

even though they look very different.

0:52

This is what's called the grade one.

0:53

And he manal cytoma is grade two or three,

0:57

and they are related

0:59

by this particular nuclear expression called stat six.

1:03

So WHO now lumps solitary fibers tumor,

1:07

and he angio cytoma as a one single tumor type

1:12

with a varying degree of aggression.

1:14

So SFT is usually grade one heman.

1:19

Cytoma is usually grade two and three.

1:22

And heman cytomas can recur anywhere else in the body.

1:26

But both these tumor types have

1:29

stat six nuclear expression,

1:32

and that is really needed to make the diagnosis of SFT

1:37

and humane, uh, cytomas in the brain.

Adult Brain Tumors Based on Molecular Genetics: Solitary Fibrous Tumors and Hemangiopericytoma

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0:00

Adult tumors.

0:01

I'm just gonna show you some

0:02

of interesting molecularly conjoined, uh, tumor types.

0:06

One is this. So meningioma

0:08

and heman cytoma,

0:10

back in the day when molecular genetics was not the,

0:13

not a thing in terms of our daily conversation, I used

0:16

to think that meningiomas and heman cytomas were related

0:21

and just that the heman of cytomas were much more aggressive

0:25

and angrier looking and destroying the bone.

0:28

And it turns out that, uh, molecular genetics have proven

0:31

that these two tumors are not related at all.

0:36

But it turns out that solitary fibrous tumor,

0:39

which is a pretty rare extra axial tumor that we see,

0:42

but elsewhere in the body too, is intimately associated

0:46

with he angio cytoma,

0:50

even though they look very different.

0:52

This is what's called the grade one.

0:53

And he manal cytoma is grade two or three,

0:57

and they are related

0:59

by this particular nuclear expression called stat six.

1:03

So WHO now lumps solitary fibers tumor,

1:07

and he angio cytoma as a one single tumor type

1:12

with a varying degree of aggression.

1:14

So SFT is usually grade one heman.

1:19

Cytoma is usually grade two and three.

1:22

And heman cytomas can recur anywhere else in the body.

1:26

But both these tumor types have

1:29

stat six nuclear expression,

1:32

and that is really needed to make the diagnosis of SFT

1:37

and humane, uh, cytomas in the brain.

Report

Faculty

Soonmee Cha, MD

Program Director, Vice Chair of Education

University of California San Francisco Medical Center

Lesson

Introduction

Lesson

Meningiomas

Lesson

Non-glial Tumors

Lesson

2021 WHO CNS Tumor Classification

Lesson

Gliomas

Lesson

Pediatric Brain Tumor Cases

Adult Brain Tumors Based on Molecular Genetics: Solitary Fibrous Tumors and Hemangiopericytoma