0:00

Here the circumscribed tumor.

0:02

And if you look at these three very different histologically

0:05

tumors have a nodule and cyst, nodule

0:08

and cyst, nodule and cyst.

0:12

These are pilocytic, astrocytomas, ganglio gliomas

0:16

and pleomorphic zho astrocytomas

0:19

and some of the super tentorial

0:22

of these three types share a molecular marker called

0:27

BAFV 600 E mutation.

0:30

At our institution in some of these patients

0:33

with this particular mutation,

0:34

they have a anti BRAF therapy they're in clinical trials for

0:39

and we are getting pretty good response to therapy.

0:43

There're, again, three very different histologically,

0:47

but imaging wise, I always knew they kind of looked similar

0:51

because they share this shape, uh, this pattern

0:54

of nodule and assist.

0:57

And a lot of the super tentorial, pilocytics, ganglio

1:01

and PX A have B-R-A-F-V 600 E mutation.

1:06

Very interesting. And this is a paper

1:09

from more than decade ago

1:11

that already looked at over 1000 tumors, uh, XA

1:16

pilocytic and glioma,

1:18

and has shown that up to 60 70% of these tumors will harbor

1:24

B-R-A-F-V 600 E mutation.

1:27

So these work has been going on for decades,

1:30

even though it now just made it to the 2016

1:34

and 2021 WHO.

1:37

The work has been going on for decades to come

1:40

to the fruition and make it into the classification scheme.

Adult Brain Tumors Based on Molecular Genetics: Circumscribed Gliomas

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0:00

Here the circumscribed tumor.

0:02

And if you look at these three very different histologically

0:05

tumors have a nodule and cyst, nodule

0:08

and cyst, nodule and cyst.

0:12

These are pilocytic, astrocytomas, ganglio gliomas

0:16

and pleomorphic zho astrocytomas

0:19

and some of the super tentorial

0:22

of these three types share a molecular marker called

0:27

BAFV 600 E mutation.

0:30

At our institution in some of these patients

0:33

with this particular mutation,

0:34

they have a anti BRAF therapy they're in clinical trials for

0:39

and we are getting pretty good response to therapy.

0:43

There're, again, three very different histologically,

0:47

but imaging wise, I always knew they kind of looked similar

0:51

because they share this shape, uh, this pattern

0:54

of nodule and assist.

0:57

And a lot of the super tentorial, pilocytics, ganglio

1:01

and PX A have B-R-A-F-V 600 E mutation.

1:06

Very interesting. And this is a paper

1:09

from more than decade ago

1:11

that already looked at over 1000 tumors, uh, XA

1:16

pilocytic and glioma,

1:18

and has shown that up to 60 70% of these tumors will harbor

1:24

B-R-A-F-V 600 E mutation.

1:27

So these work has been going on for decades,

1:30

even though it now just made it to the 2016

1:34

and 2021 WHO.

1:37

The work has been going on for decades to come

1:40

to the fruition and make it into the classification scheme.

Report

Faculty

Soonmee Cha, MD

Program Director, Vice Chair of Education

University of California San Francisco Medical Center

Lesson

Introduction

Lesson

Meningiomas

Lesson

Non-glial Tumors

Lesson

2021 WHO CNS Tumor Classification

Lesson

Gliomas

Lesson

Pediatric Brain Tumor Cases

Adult Brain Tumors Based on Molecular Genetics: Circumscribed Gliomas