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Wk 5, Case 2 - Review

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0:04

The next patient is per gang, uh, patient.

0:09

And this is a straightforward patient.

0:14

This patient had a, a vehicle per gang, again,

0:19

per gang can be evaluated with do.

0:23

It's nice, right?

0:25

Usually we used to, it might PG

0:27

for this patient, if you guys remember.

0:29

And um, it's very nice.

0:32

And um, but Dotatate now is widely replacing, uh, MI BG just

0:37

because pe CT has better image quality,

0:40

better sensitivity than spec ct.

0:42

Um, of course ITM mi BG is an

0:44

or different analog is much, is, is,

0:48

um, an analog, right?

0:51

So it's a different target.

0:53

Bo Bergen gliomas will be usually avid for both

0:58

of them, right?

0:59

Will express the somatostatin receptors

1:02

and uh, the more specific trace tracer is

1:05

of course the MIPG.

1:07

But, um, many, many studies shown that, um,

1:12

both the DOTATATE

1:13

and MIPG uh, perform, uh, similarly equally.

1:18

But the advantage of P ct, um, made most of us, you know,

1:23

move, uh, toward doing preferring PET over uh,

1:28

MR bg just because of the pet advantage as you see here.

1:31

So this is a case of, um, big bargain

1:39

nicely intensely.

1:42

SS the avid here as you see,

1:50

we have other cases of course, when you have a case

1:52

with metastatic disease also, this is very valuable too, um,

1:57

for initial staging for follow up.

1:59

And then also this, this is good for eligibility

2:03

for um, treatment.

2:04

Whether it depends are we gonna treatment?

2:07

I want 31 my pg, so we have to do an RPG scan to assess

2:11

for e are we gonna treat with tthe, which is not,

2:15

it's gonna be off-label treatment.

2:16

So tthe is if they approved for treatment for um, gnet,

2:21

which is gastrointestinal, pancreatic, neuro, the consumer,

2:24

but sometimes it's used as off-label for um, other tumor

2:29

that express malus.

2:33

Otherwise look here through the body, there's nothing else.

2:36

This is just a simple head

2:39

and neck per gang showing you

2:41

that it expresses smash statin receptors.

2:43

Intensity is the other thing is that uh,

2:48

if you are having a patient with neuroendocrin tumor,

2:52

let's say a small bowel mid gut neuroendocrin tumor

2:54

with metastatic with direct nodes and maybe liver meds

2:57

and there's nothing else, and boom,

2:58

There is a focal activity in the head and neck.

3:01

Don't rush and think that this is metastatic cervical lymph

3:03

node because it doesn't make sense, right?

3:05

There's nothing in the mest

3:07

and there's no tracking lymph nodes all the way up

3:09

and it's not gonna just boom pesticides to the, the head

3:12

and neck most think about paragangliomas

3:15

'cause par almost express what's the receptors?

3:17

And they are do avid.

3:19

So keep this in mind, keep that, keep in mind the

3:23

lum must well light up like, uh,

3:26

a light bulb in, uh, ate.

3:30

There's nothing else. This,

3:32

the rest are all physiologic activity, right?

3:37

So the tests, see how it's photonic here nicely.

3:40

This is this.

Report

Please note: Items with dashed lines (--) are information withheld as it is not relevant for you to arrive at the correct findings and impression for the report and/or it was withheld for privacy information. The items were left in to show you the typical information documented in a PET report.

Clinical Indication:
--year old male presenting for evaluation of vagal paraganglioma.

Technique:
Preparation: --- Somatostatin Analogue Therapy.
Radiopharmaceutical: --- mCi of ---- dotatate (DETECTNET), a somatostatin analogue (SSA), administered IV at ---- at ---.
Incubation interval: ---minutes.
Oral contrast: ---.
Positioning: ---.
PET/CT scanner: -----.
PET/CT acquisition: Vertex-to-mid-thighs.
Standardized uptake value (SUV): Corrected for body weight only.
CT: Non-breath-hold, without intravenous contrast.
TOTAL DLP (Dose Length Product): --- mGy*cm.

Comparison/Correlation:
--

Findings:
Technical quality: --------.
Measurements: Unless otherwise specified, all SUVs refer to maximum value in the target.
Reference: mean SUV liver: --.
CT linear measurements performed on axial images.


Head and Neck:
Hypodensity of the anterior limb of the right internal capsule and right corona radiata without associated SSA avidity, likely vascular insult.
Intensely SSA-avid soft tissue fullness within the right parapharyngeal region slightly inferior to the right fossa of Rosenmuller.
No additional foci of suspicious SSA avidity in the head and neck.
Unremarkable thyroid.


Chest:
No suspicious SSA-avid lesions in the chest.
Bilateral apical and middle lobe scarring.
There is upper lobe predominant emphysema.
No suspicious pulmonary nodules or is limited due to low-dose study technique.
Sequelae of prior granulomatous insult.


Abdomen and Pelvis:
No suspicious SSA-avid lesions within the abdomen and pelvis.
There may be mildly prominent SSA avidity associated with the distal esophagus where there appears to be a small hiatal hernia, likely reflux disease.
Unremarkable liver, spleen, adrenal glands and pancreas.
No suspicious retroperitoneal, pelvic or inguinal lymphadenopathy.
No ascites.
Ectasia of the distal infrarenal abdominal aorta, measuring up to 3.0 cm.
Calcified atherosclerotic changes.


Skeleton and Soft Tissues:
No SSA avid osseous or soft tissue lesions.
No aggressive lytic or sclerotic lesions.
No thoracolumbar compression fractures.

Impression:
1. Intensely SSA avid right parapharyngeal soft tissue lesion, likely representing the known vagal paraganglioma.
2. No suspicious SSA-avid or enlarged cervical adenopathy.
3. No convincing evidence of SSA-avid regional or distant metastatic disease.

Case Discussion

Faculty

Riham El Khouli, MD

Associate Professor of Radiology, Chief, Division of Nuclear Medicine/Molecular Imaging & Radiotheranostics

University of Kentucky

Michael F. Shriver, MD

Director of Nuclear Medicine

Proscan-NCH Imaging

Tags

PET/CT DOTATATE

PET

Nuclear Medicine

Head and Neck

CT