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Wk 1, Case 1 - Review

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0:04

I use this case for the first week, uh,

0:06

to go through my search pattern.

0:08

I hope you already went through that so quickly.

0:11

Just going quickly through it, there is, um,

0:13

nothing in the brain really to, uh, attract your attention.

0:18

Um, changing the intensity pattern,

0:23

there is a brown fat, as I explained

0:25

before, this is the, um, exact pattern

0:28

for the brown fat neck.

0:30

Bilateral symmetric,

0:31

beautiful bilateral neck Cleve accelerate

0:35

intercostal, superior mediastinal.

0:37

If you look here in the pet only,

0:42

and you look where it is exactly in the Fus image, in the CT

0:47

and correlated, it's just fat.

0:50

It's a typical pattern for, for brown fat.

0:52

And your clue is just look at the map, the map,

0:55

give it away right away.

0:57

This is a typical pattern for brown fat.

0:59

You'll get used to it. You will see it a lot specific,

1:02

especially that we're getting into the, um, winter.

1:05

Now we see increasingly in the fall

1:08

and winter months, more in younger patient, thinner females.

1:14

Um, as you see here

1:16

and going through, there is nothing as you see,

1:19

this was an example of a normal FDG, just to get used

1:23

to the normal pattern, normal bio distribution.

1:25

Once you start looking at pet

1:27

or general nukes in gen, any nuclear medicine,

1:31

anytime you are starting a neurology, pharmaceutical,

1:34

you have to get yourself used to how does, uh, the normal,

1:38

uh, biodistribution of the ED pharmaceutical historical,

1:42

so FDG, the workhorse brain is your glue.

1:46

You look at the MEB

1:47

and you see a brain, it has to be an FDG, right?

1:50

Cardiac uptake is variable depending on many things.

1:54

The most important is how long did this patient fast.

1:57

So there, for example, this, there's a lot of FDG uptake

1:59

of the, uh, heart,

2:01

which means this patient was ly fasted only for six hours.

2:04

Prolonged fasting.

2:05

If the patient fasted for 12 hours, so let's say the patient

2:08

had, um, like an afternoon, um, appointment

2:13

and he would fasted from the night

2:14

before, you will not have any myocardial uptake,

2:17

for example, right?

2:19

He, you'll have liver uptakes pain uptake,

2:21

of course excreted through the kidney.

2:22

So you'll have, uh, bial, uh, collection collecting system,

2:27

uh, draining through the ureters and bladder.

2:30

Um, variable bowel uptake.

2:33

Some, sometimes you'll have a lot

2:34

of intense uptake in the bowel

2:35

because a lot of our patients are diabetic,

2:38

are on metformin.

2:39

This is a known effect.

2:41

Um, and um,

2:45

in this patient there is mild marrow uptake.

2:48

This is a little bit more than uh, what we usually see.

2:51

Maybe this patient is a little bit anemic and we look here.

2:54

If you look here, there is the

2:57

blood here is a little bit hypo

2:58

Attenuating. So

2:59

most probably the patient is a little bit ic.

3:02

This is why we see that the mirror is a little

3:03

bit hyper functioning.

3:06

More than that, the,

3:08

usually the testicles are a little bit hot,

3:10

sometimes a little bit hotter than that.

3:12

This is physiologic. There's nothing,

3:13

um, abnormal about that.

3:15

Just looking at the pattern, going back

3:17

to our normal search pattern.

3:20

Um, you look at the lungs quickly, you just, I, we need

3:24

to go through five cases, so I'm not

3:26

gonna take a lot of time.

3:28

You see here, there are auxiliary lymph nodes.

3:32

That's normal. They look benign on the CT here.

3:37

Nice thin cortex, fatty hilum avid.

3:41

So what they can be mildly to moderately avid,

3:44

the accelerated inguinal lymph node.

3:46

Otherwise they look benign.

3:47

There is nothing, um, really, um, catching my eye on it.

3:51

There's some uptick here in the scapula,

3:53

but when I look at it, it's,

3:56

there is nothing abnormal in this uptake.

3:58

I think it's just benign uptake.

4:05

And we scan the, I mean, I'm not gonna go through this case.

4:07

We looked through this case already, already.

4:09

You guys, all of you got the

4:11

chance to look through the case.

4:12

There is no nodules in the lung,

4:17

no lymph nodes.

4:20

The liver looked nice,

4:26

adrenal glands are okay.

4:29

There was nothing really, um,

4:31

to attract your attention in this case.

4:34

The reason why we included this case, just

4:36

to show you the normal, uh, biodistribution, the normal.

4:39

But one thing I wanted to show you here is this here, um,

4:46

here, this, the activity here, the,

4:49

the brown fat even can be hot in the submarine region.

4:52

So don't get confused.

4:54

This is still a brown fat act activation.

4:57

So it can be, uh, brown fat activation can, uh,

5:00

appear in very weird location.

5:02

So don't be, uh, fooled with this.

5:05

Some patients have very, uh,

5:07

intense prompt activation in a weird location.

5:10

Um, don't forget to look at the exile Corona,

5:14

the coronal sagittal pet only ct.

5:17

And uh, I have it in the other monitor.

5:19

You are not seeing it. So I'm not gonna do this

5:21

because I don't wanna waste your time.

Report

Please note: Items with dashed lines (--) are information withheld as it is not relevant for you to arrive at the correct findings and impression for the report and/or it was withheld for privacy information. The items were left in to show you the typical information documented in a PET report.

Clinical Indication:
Weight loss, unintended. Progressive cognitive decline, diplopia, lack of sleep, and possible seizures. Low NMDAR titers in CSF per the electronic medical record. Evaluation for treatment planning.

Technique:
Preparation: Last oral intake (except water) on --at --.
Diabetic: --.
Blood glucose at time of FDG administration: --- mg/dL.
Radiopharmaceutical: -- mCi of F-18 FDG administered IV at -- at --.
Incubation interval: -- minutes.
Oral contrast: --.
Positioning: Arms raised
PET/CT scanner: ---.
PET/CT acquisition: Vertex-to-midthigh.
PET reconstruction method: ---
Standardized uptake value (SUV): Corrected for body weight only.
CT: Low-dose, non-breath-hold, without intravenous contrast.
TOTAL DLP (Dose Length Product): -- mGy cm.

Comparison/Correlation:
No relevant prior imaging for comparison

Findings:
Technical quality: Diagnostic.
Measurements: Unless otherwise specified, all SUVs refer to maximum value in the target and all CT linear measurements are performed on axial images.

Reference: mean SUV liver: ----


Head and Neck:
No suspicious hypermetabolic activity in the head or neck.
Specifically, no suspicious focal sites of increased or decreased metabolic activity in the brain, significantly different from background.
No pathologically enlarged or hypermetabolic cervical lymph nodes.
No abnormal thyroid activity.
Brown fat activity.


Chest:
No suspicious hypermetabolic activity in the chest. Bilateral supraclavicular axillary and superior mediastinal brown fat activity.
No suspicious pulmonary nodules or masses. No focal consolidation.
No hypermetabolic mediastinal, hilar, or axillary adenopathy. No pleural or pericardial effusion. No abnormal esophageal activity.
Normal caliber of the thoracic aorta.


Abdomen and Pelvis:
No suspicious hypermetabolic activity in the abdomen or pelvis.
Solid Abdominal Organs: No focal hypermetabolic activity in the liver significantly greater than the heterogeneous physiologic uptake. Unremarkable noncontrast appearance of the liver. Normal gallbladder. No hydronephrosis. Unremarkable spleen. No suspicious adrenal masses. No suspicious pancreatic findings.
GI Tract/Mesentery/Peritoneum: Physiologic bowel activity, without suspicious focal FDG uptake. The large and small bowel appear normal in caliber. No suspicious peritoneal/mesenteric findings.
Lymph Nodes: No pathologically enlarged or hypermetabolic lymph nodes in the abdomen or pelvis.
Pelvic Viscera: Unremarkable prostate gland. Distended urinary bladder.
Vasculature: Normal caliber of the abdominal aorta.
Free Fluid: No ascites or drainable fluid collection.


Skeleton and Soft Tissues:
No suspicious hypermetabolic activity in the visualized osseous structures.
No aggressive osseous lesions.
No suspicious soft tissue foci.
Diffuse heterogenous FDG activity localizing to fat within bilateral neck, supraclavicular, suprasternal, mediastinal, axillary, and medial intercostal region, in a pattern suggestive of physiologic brown fat activation.

Impression:
1. No evidence of FDG-avid primary or metastatic disease.

Case Discussion

Faculty

Riham El Khouli, MD

Associate Professor of Radiology, Chief, Division of Nuclear Medicine/Molecular Imaging & Radiotheranostics

University of Kentucky

Michael F. Shriver, MD

Director of Nuclear Medicine

Proscan-NCH Imaging

Tags

PET/CT FDG

PET

Oncologic Imaging

Nuclear Medicine

CT