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Wk 2, Case 4 - Review

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0:04

Neck cancer as well, comes with big neck mass.

0:08

Right. Biopsy come back. Squamous cell carcinoma.

0:14

Right. They're sending for staging

0:15

and also hoping that we can identify the primary site.

0:20

We know a lot of time these patients are, um, based

0:24

with the tongue primary or consular primary.

0:27

We know that, but sometimes, like this case,

0:31

we couldn't identify the primary site.

0:33

Right. Did we? I don't think we did.

0:40

So these are, um, patients.

0:43

It's, we, we know that some patients will come.

0:46

We have unknown primary sites.

0:51

It's usually a lot of them are head, neck cancer.

0:53

The other entity that we have unknown, uh,

0:56

primary is the melanoma sometimes comes, um,

1:00

the static disease with unknown primary

1:03

and um, with, uh, patient comes.

1:06

Um, and um,

1:11

we still do not know where is the primary site

1:13

ambitions are treated.

1:15

Um, for um, all the like for

1:21

extended extended time.

1:23

And we never really, we, we really never

1:26

identified the primary site.

1:32

Yeah, I was just confirming that.

1:34

I I as a, as far, okay,

1:36

other thing I wanna show you here is this.

1:38

You see this here for collectivity here

1:40

and it's in the, it's a, it's a, um, oops, sorry.

1:50

It isogenic disease. This here, which is here. Yeah.

1:56

What I, I on this see

2:02

and sometimes you see this

2:03

and there's a small lymph node that is hypermetabolic

2:05

and you know this is reactive inflammatory just

2:07

because there's vision has a autogenic disease,

2:09

a root canal or something.

2:11

So just don't over pull it. Right.

2:14

So this is a, they come for two reasons.

2:18

One for, um, hoping that we can identify the primary 'cause.

2:21

FDG is very good in that a lot

2:22

of time we do identify the primary,

2:24

but I, they wanted a case of unknown primary where we,

2:28

we can't because sometimes we cannot identify the primary.

2:31

Sometimes we can identify a primary that nothing,

2:34

nobody else can, but sometimes we cannot.

2:37

Um, and also it's good for staging.

2:39

So the staging is that we have this big lymph node,

2:42

few other smaller lymph nodes like this one here

2:48

and um, two B lymph node.

2:50

Uh, right. And then what is the more important?

2:54

The more important is that nothing else, right?

2:58

Noticed distant disease. I tried to pick

3:02

for you guys cases that are simple, not complicated.

3:07

When you start working in, um, pet reading,

3:11

more pet depends also on

3:14

where are you reading really In private centers usually get

3:18

the simple cases you work.

3:21

If you're working on a university,

3:23

usually we get more complicated cases here, see the torso

3:28

simply nice and nothing, no evidence of disease.

3:32

So it just, uh, know the disease in the neck and that's it.

3:35

Know the standards. Okay.

3:37

So we stage the case for them as well.

3:41

So know that a lot of time we can help

3:44

finding the primary side,

3:46

but sometimes you cannot find the primary side.

3:48

There are theories about that.

3:49

There are theories about the immune system

3:52

that the primary side is small, the static to a lymph node,

3:54

then the immune system takes care of the primary side,

3:58

but the lymph nodes start growing there.

4:01

There there's a, a theory about that.

4:03

Um, why some cancers, we find the static disease,

4:07

but we never really find the primary side, stuff like that.

4:10

There are some theories about this because it's a dilemma.

4:13

Dilemma. Oncology word.

Report

Please note: Items with dashed lines (--) are information withheld as it is not relevant for you to arrive at the correct findings and impression for the report and/or it was withheld for privacy information. The items were left in to show you the typical information documented in a PET report.

Clinical Indication:
---year-old male recently diagnosed with metastatic HPV positive squamous cell carcinoma to cervical lymph nodes with unknown primary. Patient presents for initial evaluation and treatment planning.

Technique:
Preparation: Last oral intake (except water) on --at --.
Diabetic: --.
Blood glucose at time of FDG administration: --- mg/dL.
Radiopharmaceutical: -- mCi of F-18 FDG administered IV at -- at --.
Incubation interval: -- minutes.
Oral contrast: --.
Positioning: Arms raised
PET/CT scanner: ---.
PET/CT acquisition: Vertex-to-midthigh.
PET reconstruction method: ---
Standardized uptake value (SUV): Corrected for body weight only.
CT: Low-dose, non-breath-hold, without intravenous contrast.
TOTAL DLP (Dose Length Product): -- mGy cm.

Comparison/Correlation:
--

Findings:
Technical quality: Diagnostic.
Measurements: Unless otherwise specified, all SUVs refer to maximum value in the target and all CT linear measurements are performed on axial images.

Reference: mean SUV liver: ----

Head and Neck:
Intensely hypermetabolic necrotic right cervical level 2A/3 level nodal conglomerate measuring 3.4 x 3.2 cm with a maximum SUV 10.
Additional small mildly hypermetabolic 0.7 cm right level 2B lymph node with SUV max of 3.1, also worrisome for metastatic nodal involvement.
No definite hypermetabolic primary site identified.
Mild to moderate FDG activity fusing to the right maxillary second premolar cavity (maximum SUV 4.8) and left mandibular first molar tooth root, representing odontogenic disease.


Chest:
No suspicious hypermetabolic activity in the chest.
No suspicious pulmonary nodules or masses.
No suspicious mediastinal, hilar, or axillary adenopathy.
Normal caliber of the thoracic aorta.


Abdomen and Pelvis:
No suspicious hypermetabolic activity in the abdomen or pelvis.
Solid Abdominal Organs:
No focal hypermetabolic activity in the liver significantly greater than the heterogeneous physiologic uptake.
Unremarkable non-contrast appearance of the liver.
Normal gallbladder.
No hydronephrosis.
Unremarkable spleen.
No suspicious adrenal masses.
No suspicious pancreatic findings.
GI Tract/Mesentery/Peritoneum:
Physiologic bowel activity, without suspicious focal FDG uptake.
The large and small bowel appear normal in caliber.
No suspicious peritoneal/mesenteric findings.
Lymph Nodes: No suspicious pathologically enlarged or hypermetabolic lymph nodes in the abdomen or pelvis.
Pelvic Viscera: Unremarkable pelvic viscera.
Vasculature: Normal caliber of the abdominal aorta.
Free Fluid: No ascites or drainable fluid collection.


Skeleton and Soft Tissues:
No suspicious hypermetabolic activity in the visualized osseous structures.
No aggressive lytic or sclerotic lesions.

Impression:
1. Intensely hypermetabolic right cervical level 2A/3 nodal conglomerate and a smaller mildly hypermetabolic right level 2B lymph node, consistent with biopsy proven nodal metastasis.
2. No definite metabolically active primary site identified.
3. No convincing evidence of metabolically active distant metastatic disease.

Case Discussion

Faculty

Riham El Khouli, MD

Associate Professor of Radiology, Chief, Division of Nuclear Medicine/Molecular Imaging & Radiotheranostics

University of Kentucky

Michael F. Shriver, MD

Director of Nuclear Medicine

Proscan-NCH Imaging

Tags

PET/CT FDG

PET

Nuclear Medicine

Lymph Nodes

Head and Neck

CT