0:00

Toxic conditions.

0:01

So again, just so you know,

0:02

kids put stuff in their mouths, right?

0:04

So, um, glipizide poisoning, um,

0:07

this was essentially like a diffuse cerebral edema,

0:09

but gabatone is, uh, used for infantile spasms.

0:12

And so that's a GABA analog.

0:14

So you can actually get, uh, some reversible, um, injury

0:17

to the, to the deep gray nuclei.

0:19

Um, withdrawal from maternal opioids can give

0:23

you a number of features.

0:25

And then even the synthetic opioids, like, uh,

0:27

because they don't clear well

0:29

and infants can give you quite a bit

0:30

of injury if you accidentally overdose.

0:33

And then finally tumors. So, uh, neonatal tumors are rare.

0:36

Um, a lot of them are these Desmoplastic Glo gliomas,

0:38

which are great, W2 grade one.

0:40

So they have some cystic components

0:42

and peripheral nodular components,

0:44

but they're pretty indolent even though they look bad.

0:47

Uh, the hemispheric gliomas are high grade,

0:49

and this is the infant types.

0:50

So these have been recently described,

0:51

so these are pretty aggressive.

0:53

And then, uh, teratoma, you know, especially immature ones,

0:56

don't have a good prognosis.

0:57

But again, this is kind of, you know, uh,

0:59

germ cell restricted diffusion calcification.