0:00

Okay, so let's go into classic cases.

0:03

So, uh, preterm, so preterm brain injury.

0:05

So there's a couple classifications

0:08

of preterm birth clinically, so indicated as an iatrogenic.

0:11

So the mom had preeclampsia, right?

0:13

There was, um, you know, rupture of memories or something.

0:16

And basically the, the, the child has to be delivered.

0:18

There's no choice otherwise to keep them, you know,

0:21

in utero would cause more harm.

0:23

And then there are spontaneous ones, right?

0:24

So, um, for whatever reason, genetic

0:26

or some environmental thing, you know, maybe lifestyle

0:29

with smoking, whatever.

0:30

Uh, for whatever reason,

0:32

the preterm birth just starts spontaneously.

0:34

And it's really a cascade of vascular and

0:36

or inflammatory factors that leads to this

0:38

that we're still really trying to understand better.

0:41

Um, and the problem of course, with preterm birth is

0:43

that you have many immature organ systems.

0:45

The neuroglial precursors are all immature.

0:47

Birth is a traumatic event going from in utero to ex utero.

0:50

And so you have these, you know, fryable vessels

0:53

and other things that are being damaged

0:55

with the primary insult,

0:56

and then also secondary and tertiary, right?

0:58

So you're getting ongoing destruction cycle

1:01

and then long-term dis maturation, um, therapy.

1:06

So they have tocolytic to try to slow down delivery.

1:08

And then just things to help decrease inflammation,

1:11

reduce infection, keep the, you know, uh, small,

1:15

small child warm, um, keep them ventilated, right?

1:18

And then the big one for preterm is this kangaroo care,

1:21

which is, you know, what's kangaroo care?

1:23

So it's basically like skin to skin contact

1:25

between the mother and the baby.

1:26

So it helps both of them, right?

1:27

It helps with the bonding, it helps with like microbiome

1:31

and, you know, breast milk and stuff.

1:32

So that the, the, this neonate is getting like the,

1:36

you know, a lot of the kind

1:37

of protective factors from the mother

1:38

that they have lost from,

1:40

from being the preterm birth and so forth.

1:42

So the idea is like, like this tree kangaroo, right?

1:44

Is that basically, you know, if you,

1:46

if you look at a newborn kangaroos this tiny pink hairless

1:48

thing and it has to crawl its way up to the pouch

1:51

and like find the, find the tet.

1:53

So, you know, honestly, like humans have it a lot easier

1:56

'cause we have all this exogenous support,

1:58

but yeah, that's the idea, right?

1:59

So basically it has to sit in there and mature

2:00

and have skin to skin contact.