0:01

So what are some of the risk factors

0:02

for developing colorectal cancer?

0:04

Some would say age itself in that, um, anyone over the age

0:08

of 50 years, um, is considered an increased risk in 90%

0:13

of colorectal cancers occur in the over, uh,

0:16

50 year old patient population.

0:19

There are certain known familial factors,

0:21

so familial adenomatous, uh, polyposis syndrome,

0:24

Gardner syndrome, uh, a sub, uh, cohort,

0:28

the Ashkenazi Jewish, uh, population,

0:31

and this is all three of these are thought related

0:34

to the adenomatous polyposis coli gene,

0:37

which is located on chromosome number five.

0:40

Then we have the, uh, hereditary, uh,

0:43

non polyposis colorectal cancers.

0:47

African Americans are also known to have, uh, increased, uh,

0:51

risk for colorectal cancer.

0:54

Um, and then if you have a personal

0:56

or a family history, by that I mean a first degree relative,

1:00

um, who has had a colorectal cancer

1:02

or adenomas polyps that, uh, increases your risk

1:07

in women if you have had a history of ovarian,

1:09

endometrial or breast cancer.

1:11

This also, uh, increases your risk

1:15

then in patients with inflammatory bowel disease

1:18

of chronic nature.

1:19

So typically over 10 years of duration, uh,

1:22

this increases your risk.

1:24

And this is more common in ulcerative colitis,

1:27

um, than Crohn's.

1:29

And this, uh, pie chart just basically demonstrates

1:32

that there are known risk factors, um, the hereditary types.

1:36

However, by far the largest piece of this pie

1:40

are the sporadic cases in patients who are average risk, uh,

1:43

with no known risk factor.

1:47

There are also some environmental risk factors as well.

1:50

Um, and when you look at the list, it's uh,

1:52

basically everything that's bad for you.

1:55

So, low fiber, high fat diet, um, eating lots of red meat,

1:59

inactivity, having a high BMI smoking and.