0:00

So let's start with Medulloblastoma.

0:03

Medulloblastoma. Now genetically are divided into four main

0:07

types and these, some of you're already familiar

0:11

with the wind, Sonic Hedgehog, and Group three

0:15

and group four and our colleagues from Stanford published

0:19

this beautiful paper,

0:21

and this was already nine years ago, uh,

0:24

showing the imaging difference between the four subtypes,

0:28

the wind, the Sonic HEA group three and group four.

0:32

And it turns out that, uh, wind type

0:35

of medulloblastoma are almost always, um, off midline.

0:40

And they're not in the fourth ventricle only.

0:43

They almost simulate a CP angle schwannoma,

0:47

that's the wind type.

0:49

Sonic hedgehog are usually the hemispheric tumors

0:52

with this multinodular solid component.

0:56

And there's two different types of it,

0:58

but we are only going to just mention

1:00

that this is a sonic hedgehog.

1:02

And then these are the more common pediatric babies

1:05

and infants, uh, can get this type of tumor

1:08

where the tumor is in the dead midline

1:11

and some enhances avidly and some don't.

1:15

And it turns out that the fourth ventricular midline tumor

1:19

of mesoblast with avid enhancement are more likely

1:22

to be grade group three,

1:24

and the less enhancing subtype tends to be group four.

1:28

I find this fascinating that imaging,

1:32

although it's not a hundred percent,

1:33

can give us a GLA into potential genetic

1:38

and molecular subtypes.

1:40

So here's the fourth main subtypes.

Pediatric Brain Tumors Based on Molecular Genetics: Medulloblastomas

HIDE

Prev Next

Interactive Transcript

Pro Tip: Click on a word in the transcript to jump to that point in the video

0:00

So let's start with Medulloblastoma.

0:03

Medulloblastoma. Now genetically are divided into four main

0:07

types and these, some of you're already familiar

0:11

with the wind, Sonic Hedgehog, and Group three

0:15

and group four and our colleagues from Stanford published

0:19

this beautiful paper,

0:21

and this was already nine years ago, uh,

0:24

showing the imaging difference between the four subtypes,

0:28

the wind, the Sonic HEA group three and group four.

0:32

And it turns out that, uh, wind type

0:35

of medulloblastoma are almost always, um, off midline.

0:40

And they're not in the fourth ventricle only.

0:43

They almost simulate a CP angle schwannoma,

0:47

that's the wind type.

0:49

Sonic hedgehog are usually the hemispheric tumors

0:52

with this multinodular solid component.

0:56

And there's two different types of it,

0:58

but we are only going to just mention

1:00

that this is a sonic hedgehog.

1:02

And then these are the more common pediatric babies

1:05

and infants, uh, can get this type of tumor

1:08

where the tumor is in the dead midline

1:11

and some enhances avidly and some don't.

1:15

And it turns out that the fourth ventricular midline tumor

1:19

of mesoblast with avid enhancement are more likely

1:22

to be grade group three,

1:24

and the less enhancing subtype tends to be group four.

1:28

I find this fascinating that imaging,

1:32

although it's not a hundred percent,

1:33

can give us a GLA into potential genetic

1:38

and molecular subtypes.

1:40

So here's the fourth main subtypes.

Report

Faculty

Soonmee Cha, MD

Program Director, Vice Chair of Education

University of California San Francisco Medical Center

Lesson

Introduction

Lesson

Meningiomas

Lesson

Non-glial Tumors

Lesson

2021 WHO CNS Tumor Classification

Lesson

Gliomas

Lesson

Pediatric Brain Tumor Cases

Pediatric Brain Tumors Based on Molecular Genetics: Medulloblastomas