0:00

So we take a deeper dive

0:03

into taxonomy bone metastases now.

0:06

What we'll find are tumors can

0:09

be osteoblastic. So these are tumors that activate the

0:13

osteoblast to increase bone turnover

0:16

here. We see prostate cancer an

0:19

example of which match to the right front toe

0:22

temporal calvarium increasing thickening

0:25

of the calvarium in

0:28

this patient with an osteoblastic metastasis,

0:31

of course small cell lung

0:34

cancer can do the same thing as skin carcinoiduloplastoma.

0:39

now if there are patients that have Lucent lesions

0:42

politic lesions

0:44

These would be tumors that are activating the osteoclasts

0:47

to break down bone. We think

0:50

about in this category renal cell carcinomas melanomas

0:53

and of the lung cancer the non

0:56

small cell lung cancers.

0:58

Thyroid cancer as well as Non-Hodgkin's lymphoma

1:01

can also break down bone creating lytic

1:04

or Lucent lesions.

1:06

When we think about conditions that really promote both

1:09

blastic and lytic lesions breast

1:12

cancer would be a classic one as

1:15

can gastrointestinal cancers or

1:18

squamous cell carcinomas.