Interactive Transcript
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Hello, and welcome to Noon Conference, hosted by MRI Online.
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3 00:00:06,090 --> 00:00:07,950 In response to the changes happening around the
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world right now and the shutting down of in-person
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events, we have decided to provide free daily
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noon conferences to all radiologists worldwide.
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Today, we are joined by Dr. David Sarkany.
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Dr. Sarkany is a fellowship-trained body
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imaging radiologist and Program Director
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of the Radiology Residency Program
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at Staten Island University Hospital.
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In addition, he graduated from MGH with a Master
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of Science in Health Professions Education.
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Since this Noon Conference is recorded,
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unfortunately we will not be able to have our
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typical Q and A session after the presentation.
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However, the doctor has been kind enough to provide
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his email address and welcomes all of you to email
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him afterwards if you have any follow-up questions.
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That being said, thank you all
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for joining us today. Dr. Sarkany,
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I'll let you take it from here.
1:00
Hi everyone.
1:01
My name is David Sarkany.
1:03
I'm the Program Director of the Radiology
1:05
Residency at Staten Island University Hospital.
1:09
And, uh, I'm really excited to, to give
1:12
this talk on pancreatic cystic lesions.
1:14
Uh, I definitely wanna, uh, thank MRI Online and
1:19
Dr. Collins for reaching out to me, um, and giving
1:22
me this opportunity to, to speak to everyone.
1:25
Um, the way I'm approaching this topic of pancreatic
1:31
cystic lesions, and by the way, I have no financial
1:34
disclosures, is, you know, I always had trouble when I
1:38
was a, a resident with pancreatic, uh, cystic lesions.
1:42
Um, so I always found that, you know,
1:46
after reviewing the topic many, many times.
1:49
It's nice to just have, like, bullet points
1:51
and examples of the, the various lesions.
1:54
You can write chapters, uh, on this information.
1:58
But I think, especially for a resident,
2:00
for quick diagnosis purposes and even for
2:04
studying for the boards, it's nice to have
2:06
some, you know, bullet point, uh, things to
2:09
look for and some familiarity of the way.
2:12
Uh, these processes will look
2:15
on CT or MR, or ultrasound.
2:19
Okay, so let's get started.
2:21
So my objectives of this talk for you guys is,
2:25
um, describe important facts of the various
2:29
pancreatic cystic lesions that I will talk about.
2:32
Uh, identify important imaging findings.
2:36
Um, and finally outline the differential
2:38
diagnosis for pancreatic duct dilatation.
2:40
And the reason why I throw
2:42
pancreatic duct dilatation in.
2:44
Is 'cause there's a lot of cystic-type of
2:46
lesions that can be associated with it.
2:49
Um, so I think it's, uh, important to
2:51
include it when we talk about cystic lesions.
2:58
So before we start, uh, I just want to introduce
3:01
you to, uh, the ACR Appropriateness Criteria.
3:04
Um, so many of you may know what this is,
3:07
and it's, it's essentially, uh, a, a joint.
3:13
Um, collaboration of different, uh,
3:18
kinds of physicians getting together to
3:20
try to understand what would be the best
3:23
imaging modality for a disease process.
3:26
So I think it's very helpful for residents
3:28
to look at this because it can tell you what
3:30
is the best, uh, initial course of action
3:33
for imaging, but I think it's also important.
3:36
As you're developing as a resident and will become
3:40
an attending, to let your referring physicians
3:42
and colleagues know about this process because
3:46
this may help them order the right, uh, study.
3:49
So I just want to quickly just go over it.
3:53
Um, this is an example of right upper quadrant pain.
3:56
So what the ACR Appropriateness Criteria does.
3:59
Is, you know, as of the last time I checked in 2015,
4:04
there was a little over 200 kinds of, uh, uh, cases.
4:08
And, uh, they'll evaluate the cases based on the
4:11
literature to see what the best imaging modality is.
4:14
So this was an example of right upper quadrant pain.
4:17
The person had fever, a white count,
4:19
and a positive sonographic Murphy sign.
4:21
The best imaging, as most of us would know, would be a
4:25
right upper quadrant ultrasound or abdominal ultrasound.
4:28
So if you look to the, you know, the, the left
4:32
of the screen, we have a listing of all the
4:36
different kinds of modalities, and there's a
4:38
rating scale that's going from nine to three.
4:42
So if it's seven, eight, or nine, then.
4:46
It's good.
4:47
It's usually appropriate.
4:48
Four, five, or six.
4:50
It depends.
4:51
So that's when you have to take into account the
4:53
patient's clinical situation and the broader picture.
4:56
It may be a useful technique, and one,
4:59
two, and three is usually not appropriate.
5:02
And you'll see throughout your career, you're gonna
5:04
have people who are gonna be ordering studies that
5:07
are not so appropriate, and you wanna be able to help
5:10
them and educate them on what's the best thing to do,
5:14
if you look all the way to the right of the screen.
5:17
There's these circles, or little radiation circles,
5:21
and that's to tell you how much radiation dose, uh,
5:26
that's associated with, uh, the different modalities.
5:29
So clearly.
5:29
So this is, uh, a table describing
5:32
the relative radiation levels.
5:33
I'm not gonna get into any physics here.
5:35
Um, again, it's just so you're aware.
5:38
Um, so the zero means no radiation — ultrasound,
5:42
MRI — and then the more circles, the more radiation.
5:46
So clearly we have five circles here — C,
5:49
T, A, chest, A, and pelvis with contrast.
5:52
There's a lot of radiation that
5:53
will, uh, go along with that.
5:56
So it's also just an important thing to know,
5:58
because if there are modalities that will provide
6:02
the same answer, then we want to try to give the
6:05
least amount of radiation possible.
6:08
Um, clearly if the modality
6:10
requires it, it's necessary.
6:12
You have to do a CTA to rule out a GI bleed.
6:15
It is what it is then, you know, that's what we do.
6:20
Okay, so the topics I'm gonna talk about,
6:26
um, pancreatic cystic lesions are the, the
6:29
following: pseudocyst, serous cystadenoma, mucinous
6:33
cystadenoma, intraductal papillary mucinous tumor,
6:38
a simple pancreatic cyst. And I just want you to
6:41
know there are other cystic lesions, uh, not as
6:45
common, um, including cystic degeneration of adenocarcinoma.
6:50
So I'm not going to give a broad conversation
6:55
of every single possible pancreatic cystic lesion.
6:58
I want to hit on the, uh, the biggest
7:00
ones, or what I consider the biggest ones.
7:06
So let's start off with a pseudocyst.
7:08
So, um, many medical students and residents know
7:12
that pseudocysts usually occur due to pancreatitis,
7:15
and most often it could be alcoholic pancreatitis
7:19
or other various causes of pancreatitis.
7:22
Um, but occasionally it can be, um, due to trauma.
7:26
So if there's someone who was in a
7:27
car accident, or iatrogenic — you'll see
7:30
it sometimes with ERCP, for example.
7:33
Um, so those are, uh, causes of possible
7:37
pancreatitis that could at least lead to pseudocyst.
7:40
The actual concept of pancreatitis and
7:43
different terminology that's used with
7:45
pancreatitis is pretty extensive, and you could
7:48
probably, uh, write a book even about that.
7:50
So I'm not gonna get into pancreatitis itself,
7:52
'cause we're talking about cystic lesions, but
7:54
pseudocyst is a secondary, uh, complication.
7:58
So with pseudocysts, many of 'em can be
8:01
asymptomatic, but depending on the size and the,
8:05
the placement of the pseudocyst, sometimes it
8:08
can have mass effect and it can get infected.
8:12
Um, so important fact to know when
8:18
you're reading pancreatic CT or, uh,
8:20
MRI and you find a fluid collection.
8:22
Is that pseudocysts develop
8:24
after about four to six weeks.
8:26
So if you have day two of pancreatitis,
8:29
and you have a fluid collection, then
8:31
that's just a pancreatic fluid collection.
8:33
It's not a pseudocyst yet. It may develop into
8:36
a pseudocyst, um, but it's not a pseudocyst yet.
8:39
And it's a pseudocyst.
8:41
It's not a true cyst 'cause it actually has a fibrous
8:43
capsule as, uh, what, uh, contains the collection.
8:48
Interestingly enough, pseudocysts can be in any
8:52
part of the body. So clearly, most often it's
8:54
associated with the pancreas, but it can
8:57
be really in, uh, any portion of the body.
9:00
Um, and that's because the fluid can
9:01
track into different, uh, different areas.
9:07
So I just wanted to show, uh, a nice, uh,
9:10
CT example of just simple pancreatitis.
9:13
So here we have, uh, a pancreas.
9:15
Where the borders are, uh, kind of
9:18
obscured; it's kind of amorphous.
9:20
There's infiltrative changes around the pancreas.
9:24
So if you look, um, you know, higher up anterior
9:28
to the abdomen, the subcutaneous fat or the
9:30
intraperitoneal fat is very dark, but around the
9:34
pancreas, it's all kind of a, a whitish gray.
9:38
Um, so it's a perfect example of the way,
9:41
uh, acute pancreatitis would look like.
9:47
So this will be our first case, and this case
9:52
itself could be day two of pancreatitis, or it
9:55
could be, uh, the sixth week of pancreatitis.
9:58
And again, depending on the timing,
10:01
that will determine if it's pseudocyst.
10:03
But what we can say for sure is
10:05
that there are fluid collections
10:07
that are rim enhancing.
10:09
There are tons of inflammatory
10:10
changes around the pancreas.
10:11
And again, I'm only showing one image.
10:13
So you're not getting a, a great picture of the,
10:17
of the whole process, but you get a basic idea, and,
10:22
um, you know, if it's after four to six weeks, this
10:25
is a perfect example of a pancreatic pseudocyst.
10:32
So this is the same patient that they're following
10:35
up to see if the pancreatitis is, uh, improving.
10:39
This is one month later, so
10:40
we're at the four-week, uh, mark.
10:43
So these are definitely, uh, pseudocysts,
10:46
the rim-enhancing fluid collections.
10:48
Um, and there's actually two of 'em, and you
10:51
can see with the one that's larger that it is
10:55
really kind of smushing that, uh, left kidney.
10:58
And, um, it wouldn't be shocking if the patient's
11:01
having symptoms related to the, the left renal, uh,
11:05
system — UTIs, or hydro, or things of that nature.
11:10
And that's what I mean is sometimes it
11:12
can be asymptomatic, so that probably
11:14
smaller one is kind of asymptomatic.
11:16
The larger one is
11:18
causing mass effect.
11:19
It could cause mass effect on the stomach
11:21
and cause gastric outlet obstruction.
11:23
It can cause mass effect on the biliary ducts
11:26
and cause biliary duct dilatation, elevated bilirubin.
11:29
Um, so it could definitely have a, a lot of effects.
11:37
This is another case, um, it's an
11:39
example of chronic pancreatitis, and
11:41
we'll talk about a couple things here.
11:43
So the big arrow pointing to a
11:45
rim-enhancing fluid collection.
11:48
A pseudocyst.
11:49
Um, but what I'm pointing at with the pancreas
11:52
is there's a nice tubular hypodensity within the
11:55
pancreas, and that's a dilated pancreatic duct.
11:59
So going
12:00
back to, uh, my objectives, you
12:03
know, dilated pancreatic duct many times is
12:05
associated with some kind of cystic process,
12:08
and that's why I'm including it in this talk.
12:11
And then you also see white little
12:12
dots throughout the pancreas.
12:14
Those are calcifications.
12:16
So in chronic pancreatitis, um, and I'll show you
12:20
the next case that I show you, uh, will be a,
12:23
a more extreme example of chronic pancreatitis.
12:27
Um, we'll have calcifications in the pancreas, and
12:30
typically you'll have pancreatic duct dilatation.
12:33
Um, but the pseudocyst will not be communicating,
12:36
uh, will not be obviously communicating
12:39
with the, with the pancreatic duct.
12:41
Although the pseudocyst does form from,
12:45
uh, injury to the, to the pancreatic
12:48
duct or leaking of, uh, of fluid.
12:51
Um, so it's important to know for chronic
12:55
pancreatitis that you have pancreatic duct dilatation.
12:57
You'll have calcifications, um, and you may or may
13:02
not have cysts, uh, that depends on the patient.
13:09
So.
13:10
Okay, with pseudocyst treatment, um, many of 'em we can
13:15
treat conservatively, they'll regress on their own.
13:18
However, if they're symptomatic or they're getting
13:20
bigger, or they're coming back again, you
13:23
can either do surgery or endoscopic drainage.
13:27
And a lot of GI docs will stick a drain between
13:31
the pseudocyst into the stomach so that the
13:34
collection drains into, uh, the stomach.
13:36
So I've seen that a lot more recently.
13:39
Um, and I think it's a pretty, uh, easy
13:41
way to, uh, help that pseudocyst resolve.
13:49
So, previously I had mentioned that I'm
13:51
gonna give you a more complicated chronic
13:53
pancreatitis that's a little bit later on, and,
13:55
uh, when we get to it, I'll show it to you.
13:57
Okay.
13:58
Let's talk about serous cystadenomas.
14:01
Um, so this one was always, you know, a hard
14:04
one for me because they're just, they don't
14:06
occur in practice that common.
14:09
Um, so, but a few important points.
14:13
Number one, it's benign.
14:14
So that's, uh, a very important,
14:17
uh, thing to keep in mind.
14:20
More often in females, more often elderly; it
14:23
can be middle-aged, but for, you know, test
14:26
purposes or, uh, for general, trying to remember
14:31
purposes, it occurs in elderly people.
14:34
Tends to be in the head or uncinate process, and as
14:37
an aside, it can be associated with Von Hippel–Lindau.
14:44
So serous cystadenomas, the majority of them are
14:48
many tiny cysts between one to 20 millimeters,
14:51
and it's called the polycystic, uh, category.
14:54
That's the majority of them.
14:56
Um, there's a honeycomb pattern,
14:59
and there's an oligocystic.
15:00
The honeycomb pattern is the cysts are, uh, uh,
15:04
a lot smaller, and the fibrous septa are a
15:07
little bit more prominent.
15:10
The oligocystic, the cysts are
15:13
bigger than 20 millimeters.
15:16
Um, again, those two are not nearly as common.
15:20
Um, in general, serous cystadenoma was.
15:23
The cysts are separated by septa, fibrous
15:25
septa that are radiating from a central
15:27
scar, and that central scar can be calcified.
15:30
It doesn't have to be, though.
15:35
So this is not a great CT example.
15:39
Um, I'm gonna give you a sagittal image
15:41
where you see the septa a little bit more.
15:43
The arrow is kind of pointing towards a septa.
15:46
So this is a loculated fluid collection with septa.
15:49
It looks like a bunch of grapes.
15:51
Um, but I'll show you other examples
15:53
that are a little bit more obvious.
15:54
And this isn't, uh, in the head.
15:59
So here's a sagittal image.
16:00
Again, you can, you know, faintly see, faintly see,
16:04
um, you know, linear septa where a little bit more
16:08
high density than the actual cystic, uh, component.
16:12
So.
16:14
So I'm gonna show you some MRIs, but before I show
16:18
it to you, let's just, for those who don't know too
16:20
much about MRI, let's just go over two basic concepts.
16:23
Um, in the, you know, in the good old days,
16:27
um, when MRI first began, we essentially
16:30
had two sequences, T1 and T2.
16:32
Nowadays, we have tons and tons of different
16:34
sequences depending on the, uh, area of concern.
16:38
Um.
16:40
But originally, T1 was essentially kind
16:42
of like an anatomical, uh, sequence so you
16:46
can kind of get a lay of the land, know
16:49
what's going on with the general anatomy.
16:51
And T2 was more of a pathology type of sequence,
16:55
where things that are slightly bright were pathologic.
16:58
Now, if something was extremely bright,
17:01
like let's say a cyst, it's still pathologic.
17:04
It's just not malignant.
17:05
Um, so that was the purpose, uh, or
17:08
that's what T2 ended up showing us.
17:11
So again, so for the purposes of this talk,
17:13
um, T1 bright, uh, objects tend to
17:19
be fat or blood products, and T2 bright
17:23
tends to be simple fluid or blood products.
17:26
So they both can be blood products,
17:27
depending on the age of the hemorrhage,
17:30
if it's acute, or chronic, or subacute.
17:33
There will be, uh, different
17:34
kinds of signal intensities.
17:40
So this is a coronal single-shot
17:43
MRI, uh, gave a small field
17:48
of view and a larger field of view.
17:49
Um, and what I'm trying to show you here is the
17:54
serous cystadenoma right next to the stomach, and you
17:58
can kind of see a lot of little black lines in it.
18:01
It may be a little bit better on the smaller image.
18:04
Um, and again, so nowadays with MRI, there's a lot of,
18:10
uh, what I've noticed, a lot of mixing of the signals.
18:14
So here we have the stomach, which is bright.
18:17
You have the cystadenoma, which is
18:19
bright, both are fluid type of, uh.
18:22
Uh, areas, but the subcutaneous or intraperitoneal
18:25
fat is bright, so that's kind of confusing based on
18:28
what I just explained to you with T1 and T2.
18:32
The way I tell, uh, my students or residents to look
18:36
at it is, look at the fluid-based, um, structures.
18:41
If they're bright on T2, the ones that
18:44
should be bright — the gallbladder, fluid
18:46
in the bowel loops, in the bladder, if
18:49
there's no ovarian cyst or a renal cyst.
18:51
Then that sequence is a primarily
18:53
T2-weighted sequence.
18:55
So this is a — I will view this when I read
18:59
it as a primarily T2-weighted sequence.
19:02
Yes, it has some T1 components to it, um,
19:05
but it's a primarily T2-weighted sequence.
19:11
So to me, this is a much nicer picture where
19:14
you kind of get all these kind of little septations.
19:16
It really looks like a bunch of grapes.
19:18
This is, uh, a thick-slab MRCP image.
19:22
Um, and here is, uh, an axial T2 fat-sat image.
19:29
So again, T2 I know because the CSF is bright,
19:33
the stomach is bright, our cystadenoma is bright.
19:37
Um, it's fat-saturated.
19:39
So all the fat — intraperitoneal
19:41
and subcutaneous — is, uh, is black.
19:47
Just another example, again, I think you — this is
19:50
probably my best example of showing the fibrous septa,
19:53
um, and how it really looks like a, a bunch of grapes.
19:57
So this would be a classic, a no-brainer,
19:59
serous cystadenoma.
20:02
And it's important to know that,
20:03
because if you're gonna just
20:05
diagnose, you're gonna say there's
20:06
a cystic neoplasm in the pancreas.
20:09
They're gonna wanna rush to surgery.
20:11
And this is a non-surgical, uh, entity,
20:15
unless maybe it gets too big or there's,
20:18
you know, some secondary type of things.
20:20
But in and of itself, it's a benign lesion.
20:22
So just like you wouldn't remove a renal cyst,
20:24
you don't need to remove this lesion.
20:30
Just another example of those bunch of
20:32
grapes. On the right, there's an image,
20:34
it's a post-contrast T1 with fat sat.
20:38
I know it's T1 because the CSF is dark, fat sat.
20:42
The fat is dark.
20:44
And I'm telling you, there's contrast.
20:46
It's contrast in the aorta and the venous system.
20:48
You can see how the septa are enhancing.
20:52
Um, so that's a, a post-contrast.
20:59
Okay, so let's talk about
21:02
intraductal papillary mucinous tumor.
21:04
So, so far we hit on pseudocyst
21:06
and a serous cystadenoma.
21:09
So there are three different types of
21:11
intraductal papillary mucinous tumors.
21:14
Main duct, branch duct type, or what I call side branch,
21:19
or mixed, where it could be main duct and side branch.
21:25
So main duct intraductal papillary mucinous tumors
21:29
can be diffuse, involving the whole pancreatic duct.
21:31
Segmental, maybe just the body, maybe just the tail,
21:35
and it has malignant potential, some say up to 60%.
21:38
So this is a surgical, uh, lesion.
21:42
So if you diagnose, uh, main duct IPMN, then
21:47
uh, the patient will have, uh, that part of
21:49
the pancreas removed, if not the whole thing.
21:54
So this is a, a nice example where
21:56
they didn't actually do anything
21:58
for the main ducts and it got worse.
22:00
Um, it didn't get malignant in this person, but the,
22:05
the pancreatic duct dilatation, uh, got a lot worse.
22:08
I don't know if they ended up operating on this
22:10
person, but at year one, there was definitely a dilated
22:13
tubular hypodense structure involving most of the
22:16
pancreas, and that was a dilated, uh, pancreatic duct.
22:20
Now.
22:21
It's so dilated and lobulated that I had to show
22:25
it on three, uh, essentially different images.
22:27
So this is a coronal image of a
22:29
CT without IV contrast, and this
22:32
whole cystic thing is the main duct.
22:36
It's become extremely lobulated.
22:39
The, the bottom left, um, shows the
22:43
region — the pancreatic tail completely
22:46
replaced by a dilated pancreatic duct.
22:49
And then I showed another coronal because this is
22:51
the, the most, uh, distant part of the pancreas,
22:55
um, where again, the pancreatic parenchyma is
22:58
virtually all gone and it's just a, a dilated duct.
23:02
So this kind of person, the pancreas, uh, should
23:05
be removed because there is malignant potential.
23:09
So I'm gonna show a couple, uh, smaller ones.
23:14
Here's an example, um, on the left where we're
23:16
near the pancreatic body where there's a dilated
23:19
duct, and then I'm showing as it goes into the
23:21
head of the pancreas, it's a, it's a dilated duct.
23:29
This is an MRI, so this is
23:32
a UTE T2-weighted sequence.
23:35
Um, I'm showing, uh, on the
23:38
left I'm showing a white arrow.
23:40
That white arrow is supposed to be the CBD, and
23:44
the yellow arrow is a dilated pancreatic duct.
23:47
So remember, it's coronal, which means that, um,
23:51
the pancreatic tail is gonna be up in this corner.
23:54
Um, and the pancreatic head
23:56
is in, in this location here.
23:59
Um, and this is just a little bit more,
24:03
uh, distal to the pancreatic head.
24:04
We're in the pancreatic neck region where
24:08
uh, we still have that dilated, uh, duct.
24:11
We know, again, this is T2
24:13
'cause our gallbladder is bright.
24:14
We have hepatic cysts that are bright.
24:16
So even though the fat is kind of bright, we know
24:19
that this is a predominantly T2-weighted sequence.
24:26
So this goes, uh, we're right at
24:29
the point of that second chronic
24:30
pancreatitis, which is kind of complicated.
24:33
So, but it, it goes back to that dilated pancreatic
24:35
duct dilatation or, uh, discussion where, um.
24:40
It's important to keep that in mind when
24:42
you're dealing with, uh, cystic, uh, lesions.
24:45
So there is a differential diagnosis for pancreatic
24:49
duct dilatation, which we will, uh, we will get to.
24:51
But so far we've seen chronic pancreatitis
24:54
that can cause it and main duct IPMN.
24:58
So this is the chronic pancreatitis case
25:00
that I recently, uh, you know, was seeing.
25:05
I never saw anything really like this.
25:07
There's a huge pseudo mass.
25:10
Involving the pancreatic head.
25:11
Now we have tons of pancreatic calcifications,
25:14
there's pancreatic duct dilatation, and then
25:16
we got this big mass-like process here.
25:20
And let me show you on an axial image.
25:23
So this whole thing over here is a pancreatic
25:27
head lesion, and this area here might
25:31
be a pancreatic duct or a side branch.
25:33
I have no idea.
25:33
Again, I'm only showing you on one image.
25:36
I circled this area just so you know
25:37
what the SMV and the SMA are in relation
25:40
to this, uh, pancreatic lesion.
25:44
And, um, I — it's not what an adenocarcinoma would look like.
25:50
An adenocarcinoma that's this big would
25:52
probably have metastatic disease.
25:54
And commonly with chronic pancreatitis,
25:56
you can get pseudomasses that occur.
25:58
And it's not always an easy diagnosis.
26:01
It's not a, a slam dunk that it's a, it's a
26:04
pseudocyst. It's likely a pseudomass, but, you know,
26:08
follow-up and further evaluation has to be
26:10
performed just to make sure it's not an adenocarcinoma.
26:13
Um, but again, something this big would be,
26:16
uh, more likely a pseudomass.
26:20
And this person had no lymphadenopathy.
26:23
Uh, there were no liver lesions, no pulmonary nodules.
26:26
It was just the pancreas that was, uh, diseased.
26:31
So again, so here on the coronal, we're seeing
26:35
a nice dilated pancreatic duct, and as we
26:37
were talking about pancreatic duct dilatation,
26:39
chronic pancreatitis can cause it, and.
26:41
As we discussed, also main duct IPMNs can cause it.
26:48
And finally, for
26:50
pancreatic duct dilatation.
26:52
You can have a pancreatic,
26:53
adenocarcinoma, and this is an example.
26:56
The yellow circle shows a hypodense
26:58
structure within the head of the pancreas.
27:00
These are coronal images, and it's causing
27:03
distal pancreatic duct dilatation because
27:05
it's obstructing the pancreatic duct.
27:08
So now we have three things that
27:09
can cause pancreatic duct dilatation.
27:12
A central obstructing lesion,
27:14
such as an adenocarcinoma.
27:16
Um, another example could be an ampullary carcinoma,
27:20
uh, or even a, uh, a common bile duct cancer.
27:24
Um, those things can cause,
27:26
uh, pancreatic duct dilatation.
27:28
We have chronic pancreatitis, so that kind of
27:30
pancreatic duct dilatation is not malignant.
27:32
And then we have main duct IPMNs, which
27:34
are, uh, premalignant slash malignant.
27:41
This is that same case, I'm just showing, uh,
27:44
an axial image of what the body looks like.
27:47
The body is totally filled with a dilated
27:50
duct and atrophy of the parenchyma.
27:52
So a classic finding with pancreatic adenocarcinoma is
27:57
dilatation of the pancreatic duct, uh, distally.
28:00
And, um.
28:02
Atrophy of the, uh, associated pancreas.
28:05
And this person happens to have
28:06
a lot of liver hypodensities.
28:08
This is all metastatic disease to the, to the liver.
28:17
So branch duct or side branch, uh,
28:20
intraductal papillary mucinous tumors.
28:22
Um, these tend to be, uh, small cysts.
28:26
Um, and they communicate with the main
28:28
pancreatic duct and what they tend to look like.
28:31
Are, uh, berries hanging from a twig.
28:35
Um, these are usually benign.
28:36
There's a tiny percentage that, uh, can be malignant,
28:40
and there's various recommendations for follow-up.
28:42
I wasn't gonna get into, uh, all of that,
28:45
but, but we do follow these to make sure they
28:48
stay stable and they don't become, uh, worrisome.
28:54
So this is to me what a classic,
28:56
uh, side branch IPMN looks like.
28:58
So this is a single, uh, image
29:01
of a thick-slab, uh, MRCP.
29:05
Um, and we have these tiny little, uh, cystic foci
29:11
that are communicating with the pancreatic duct.
29:13
I have maybe 1, 2, 3, 4.
29:16
Um, it's a nice — the MRCPs, um, are very heavily
29:22
T2-weighted, meaning that only fluid-filled
29:24
structures are really well seen, and we see a
29:26
nice CBD that will branch into the biliary tree.
29:29
We actually see a nice cystic
29:30
duct into the, uh, gallbladder.
29:34
And then we have the nice pancreatic duct,
29:36
um, with these little tiny cystic, uh, areas.
29:41
This over here is probably a duodenal diverticulum.
29:45
So as an aside, sometimes you'll see these air
29:48
fluid collections that will be associated with the
29:51
pancreatic head, and you might think it's an abscess.
29:54
More often than not, it's just
29:56
a, uh, duodenal diverticulum.
29:59
They can be small, they can be very big.
30:02
Um, but if they don't have any, you know,
30:07
anti-inflammatory changes, it's probably just
30:09
a duodenal diverticulum, and those are benign.
30:13
Nothing to worry about.
30:17
So this is going back to, um, one of the examples of
30:21
the, the main duct IPMN that, that I was showing you,
30:25
because there was, uh, uh, a mixed component to it.
30:29
So here we have, we're in the head of the pancreas.
30:32
Again, this is a T2 fat-sat image.
30:36
CSF is bright.
30:37
Renal cyst is bright, gallbladder is bright.
30:41
Um, fat is dark because we fat-saturated it.
30:45
So in the pancreatic head we
30:46
have a very dilated, uh, duct.
30:49
And if you just look a little anterior
30:51
to it, it is a little tiny cyst.
30:53
And on the image on the right, you
30:55
can see there's a communication.
30:56
So this is what a side branch, uh.
31:01
IPMN would look like.
31:03
And it's in, uh, conjunction
31:05
with the, with the main duct.
31:11
And this is, uh, the, the same patient.
31:14
Uh, these are coronal images.
31:16
These are also a single shot.
31:18
They're, uh, again, predominantly
31:21
a T2-weighted sequence.
31:22
And that's the way we, uh, should look at it.
31:25
Yes, there's some bright in the intraperitoneal fat.
31:30
We see, uh, we see a CBD, we see a gallbladder,
31:34
we see a dilated main pancreatic duct.
31:37
We see this little cystic lesion on
31:39
the left below the pancreatic, uh, duct.
31:42
And then on the image on the right, we
31:44
see that there's some communication.
31:53
Okay, so now mucinous cystadenomas.
31:57
So these are important because these are premalignant
32:00
or malignant. Again, they're more often in females.
32:05
Um, they tend to be middle-aged.
32:07
So as opposed to those serous cystadenomas,
32:09
which tend to be more elderly, um, mucinous
32:13
tend to occur in the tail of the body. Again,
32:17
unlike serous, which tends to be in the head.
32:20
And these are macrocystic.
32:22
Sometimes they're just one.
32:23
They're a big cyst.
32:24
And that's it.
32:25
Again, different than the serous, which is
32:27
usually a lot of tiny cysts with fibrosepta.
32:30
And remember, the serous are benign, so it's important.
32:34
Serous, benign.
32:35
We're not gonna operate.
32:36
Mucinous is premalignant or malignant,
32:38
and we're gonna operate to take it out.
32:44
So before we get into, um.
32:47
Uh, mucinous.
32:48
Let's just talk a little bit
32:49
about ultrasound for some of you.
32:50
As a quick reminder, um, a simple cyst needs to be
32:55
anechoic, meaning it should be black on ultrasound.
33:00
Um, it should have a thin wall that you can't see,
33:03
and it should have posterior acoustic enhancement.
33:06
Um, I wouldn't say this is the best
33:07
example of posterior acoustic enhancement.
33:09
You can kind of see some linear black lines.
33:13
The yellow arrows point to, and then
33:15
it's kind of white, uh, centrally.
33:18
Um, so those are the three things
33:20
you want for a simple cyst.
33:23
Uh, and this structure happens to be an
33:24
ovary, but it was just a good example
33:26
of what a, a simple cyst looks like.
33:28
You can have a simple renal
33:29
cyst, a simple hepatic cyst, um.
33:35
So this is a patient who came in who I think she was
33:38
trying to get pregnant and was having abdominal pain.
33:41
We did a sono first thing.
33:44
So on the right, it's a transverse
33:46
image of the left upper quadrant.
33:48
On the left is a sagittal image, so just to
33:51
orient yourselves. On the sagittal image, the
33:55
top part is the anterior portion of the body.
33:58
The.
34:00
Back part or the, the bottom
34:01
part is the posterior portion.
34:03
And if you look, there's a, a nice kidney
34:07
that's, uh, right behind, uh, the big pseudocyst.
34:11
And this is an example of, yes, we have
34:13
the posterior acoustic enhancement.
34:15
It's very, very white over here.
34:17
But it's not really completely black.
34:20
There's a lot of little white, gray dots in it.
34:22
And that means this is a complex cyst.
34:24
Maybe there's some hemorrhage in it,
34:26
maybe there's some proteinaceous material.
34:28
Theoretically it could be infected,
34:30
um, but it's, or it could be mucin.
34:33
Um, and so it's not a typical simple cyst.
34:36
The, the image on the right is a transverse image.
34:39
So again, just to orient you, um.
34:43
The bottom over here, you kind of have a round
34:45
black structure that's your vertebral body.
34:48
Uh, a little bit further up, you have an axial image
34:52
of the left kidney, and then you have a little piece
34:55
of the spleen, and then you have this big pancreatic,
35:00
or let's say left upper quadrant cystic, uh, lesion.
35:03
At this time, it's kind of hard to
35:05
say where it's originating from, so we
35:07
ended up getting, uh, uh, a CT scan.
35:14
So here is an axial and a coronal post-contrast
35:18
CT scan showing that same big cystic lesion.
35:22
And here we actually see it's kind of nice where,
35:25
um, there's something called the claw sign where the,
35:29
uh, the parenchyma is surrounding, um, the cyst and.
35:35
When you see things like that, then you know
35:38
that that cyst originates from that structure.
35:40
So you might see it in a renal cyst,
35:43
you know, ovarian cyst, a hepatic cyst,
35:45
um, and you actually could see it displacing
35:47
the splenic vein, uh, posteriorly.
35:51
I'm showing this coronal image because again, you
35:53
see part of the splenic vein wrapping around it.
35:57
This is an artery up here.
35:59
Um, just to get you, uh, a
36:01
little bit, uh, better situated.
36:05
So then we did an MRI to try
36:08
to further characterize it.
36:11
So I had three different sequences here.
36:13
So let's just go over a little bit.
36:15
T1, T2.
36:16
So all the way on the left, the cyst is dark.
36:20
So we said that, uh, the only thing bright,
36:23
uh, on T1 would be fat or blood products.
36:27
So, um, a cyst should be dark.
36:31
On, um, on a T1.
36:32
So this is a T1-weighted sequence,
36:34
again, if we look at the CSF, it's dark.
36:37
Now, you may argue with me, well the
36:39
gallbladder looks kind of bright.
36:40
Well, first of all, the gallbladder
36:42
should look light bulb bright.
36:44
And this one looks like, you know, maybe
36:46
the top of the gallbladder is a little bit
36:48
darker and, uh, a little bit amorphous.
36:51
So this is actually a gallbladder
36:53
that has sludge in it.
36:54
So sludge in a gallbladder, 'cause
36:55
it's kind of like this proteinaceous type of
36:58
material will be, uh, bright on, uh, on T1.
37:04
Also as an aside, um, the pancreatic parenchyma is
37:07
very, uh, nice to look at on T1-weighted imaging.
37:11
The pancreatic parenchyma tends to be kind of bright.
37:14
So if you're looking for a subtle lesion, an adenocarcinoma
37:17
or something of that nature, it will be, uh, lower
37:20
in signal than the normal pancreatic parenchyma.
37:23
And sometimes that might be the
37:25
easiest way to pick up a pancreatic
37:27
adenocarcinoma.
37:29
On the right side, uh, the top right,
37:34
we have a T2-weighted sequence.
37:36
Um, again, there is a T1 component
37:39
'cause we see the fat is bright, but
37:40
that cyst is completely, uh, bright.
37:44
And finally the bottom is, again, if we look at
37:47
the CSF or the gallbladder, they're kind of dark.
37:51
Um, and the fat is dark.
37:53
This one is a T1 post-contrast with fat-sat,
37:57
and we see that the cyst remains black, that there's
38:01
no enhancement, so there is no enhancing component.
38:05
Again, that doesn't mean it's not
38:07
premalignant, it's still premalignant,
38:10
um, and still would need to be, uh, removed.
38:18
So I just like this picture
38:20
'cause it's pretty impressive.
38:21
Uh, it's a, a coronal, uh, thick slab,
38:25
MRCP, just showing this big cystic lesion, um,
38:30
you know, in the, in the left upper quadrant.
38:32
Now keep in mind, if you just had
38:35
this picture, there's a differential.
38:36
It could just be a renal cyst, it could
38:38
be a peritoneal inclusion cyst.
38:41
It could be, uh, you know, uh, other different things.
38:46
And, um.
38:47
So I'm, I'm showing this picture in context of the,
38:51
the other pictures that, that we had just gone over.
38:57
And this patient, again, a young patient, um,
39:01
had, uh, that portion of the pancreas removed.
39:03
So this was a post-op, uh, follow-up picture.
39:06
Um, that little white dense structure with a
39:09
yellow line it points to is a surgical clip.
39:12
And if you were to scroll up and down,
39:15
there's no pancreas distal to, uh, that
39:17
little piece in the pancreatic head.
39:20
Um, so just an example of what
39:22
surgery, uh, you know, will do.
39:29
So finally we'll talk about simple cyst.
39:33
Now, a simple cyst, there's no way to know
39:35
something is a simple cyst unless you actually
39:38
take it out and do histology and pathology.
39:41
Um, they're rare.
39:43
They have a true epithelial layer
39:45
as opposed to remember a pseudocyst
39:46
which will have a fibrous capsule.
39:49
And again, we won't know if it's a true simple
39:52
cyst unless you actually surgically remove it,
39:53
which we're not gonna do because they're benign.
39:56
They're common in children.
39:58
You can see them in autosomal dominant polycystic
40:01
kidney disease or Von Hippel–Lindau. Important.
40:05
They're asymptomatic, and, uh, and they're benign.
40:09
Um, so many times when we do
40:11
MRIs, we might see a cystic.
40:14
A cystic focus, and we can't definitely
40:17
say it communicates with the pancreatic duct.
40:19
Um, and so all we can do at that
40:22
point is, is give a differential.
40:24
It could be a side branch IPMN.
40:27
It could be a simple cyst.
40:28
In any case, as I had mentioned to
40:30
you earlier, side branch IPMNs
40:34
have a very tiny percentage of, uh, malignancies.
40:37
So we follow these.
40:39
Um, and there are different guidelines of sizes and
40:43
when to follow, um, and, and for how long to follow.
40:47
But keep in mind, so I'm not gonna actually
40:49
show you a, a picture of a cyst because
40:51
I can't prove it'll be a simple cyst.
40:53
Um, these are benign processes.
40:59
So just a, a, a quick review
41:02
of, uh, these general ideas.
41:06
Um, if you see a cyst in the pancreas, the
41:09
general differential diagnosis is gonna
41:12
be a pseudocyst versus a cystic neoplasm.
41:15
Again, cystic neoplasm can be serous.
41:19
It could be a mucinous cystadenoma.
41:20
It could be a degenerating adenoma.
41:22
It could be a side branch IPMN.
41:25
Um.
41:26
It could be a simple cyst.
41:29
Um, so it's important, number one, to
41:31
have some history and also to see how
41:35
it associates with the pancreatic duct.
41:37
So if you have a small cyst that's communicating with
41:40
the pancreatic duct, then it's a side branch IPMN,
41:43
and as I just mentioned, we're gonna follow those.
41:46
They don't need to be operated on, but
41:48
we follow 'em just because there's a
41:50
chance that they can become aggressive.
41:54
If it's not communicating with the
41:55
pancreatic duct, then history is pretty
41:59
important in the setting of pancreatitis.
42:03
If we have a fluid collection,
42:04
it's less than four weeks.
42:06
We're just gonna call it a peri-
42:07
pancreatic fluid collection.
42:09
Still have to follow it, still
42:10
have to see if it gets better.
42:12
These can get infected, um, and
42:15
can cause mass effect as well.
42:17
If it's greater than four
42:18
weeks, then it's a pseudocyst.
42:20
They'll have a fibrous capsule.
42:22
And again, these, uh, may regress over time or may
42:27
require surgical or, uh, endoscopic, uh, intervention.
42:31
And like I had mentioned earlier, I definitely
42:34
have seen a lot more, uh, endoscopic GI, uh,
42:38
doctors putting in, uh, little stents that
42:41
drain the cyst into the, into the stomach.
42:45
Um.
42:47
If you see something that looks like a bunch of
42:49
grapes, a lot of tiny cysts there together with a lot
42:52
of fibro septa, and we're talking about an elderly
42:55
female, and especially if it's in the head or uncinate
42:58
process, it's a serous cystadenoma, and these are
43:02
benign lesions and they do not require any surgery.
43:08
A unilocular tail lesion in a middle-aged
43:11
female will be a mucinous cystadenoma.
43:14
Um, and these are malignant, so
43:17
they're gonna require, um, uh, surgery.
43:25
And just finally, let's touch on
43:27
a dilated main pancreatic duct.
43:30
The differential diagnosis for a dilated
43:32
main pancreatic duct will be a main duct
43:34
IPMN.
43:36
Chronic pancreatitis, or obstructing pancreatic adenocarcinoma.
43:40
So main duct IPMN will essentially be
43:43
just an isolated dilated pancreatic duct.
43:46
There won't be any signs of pancreatitis.
43:48
There will not be any signs of chronic pancreatitis.
43:50
There won't be calcifications.
43:52
There, uh, won't be atrophy of, of the pancreas.
43:56
And there won't be this pseudo mass, which I had,
43:59
uh,
44:00
shown you.
44:01
And finally, with an obstructing pancreatic adenocarcinoma,
44:03
depending on where the adenocarcinoma is, and
44:06
most commonly they're in the head of the pancreas,
44:08
everything distal to that mass will be dilated.
44:13
And many times, uh, pancreatic adenocarcinomas will
44:16
cause, uh, common bile duct dilatation.
44:19
So there's something called a double
44:20
duct sign, which is a dilated common
44:22
bile duct and a dilated pancreatic duct.
44:25
Um.
44:26
So we have three different, uh, entities
44:29
that will cause a dilated main
44:31
pancreatic duct, two of which are malignant
44:34
and one of which is, uh, not malignant.
44:37
And an important thing to keep in mind with pancreatic
44:40
adenocarcinoma is its relationship to the SMA and SMV.
44:44
Way back when I showed you that
44:46
pseudomass, the mass was not.
44:48
Touching the SMA or SMV. If the mass touches,
44:51
if it's an adenocarcinoma and the mass touches the SMA
44:55
and SMV, it will affect surgical planning.
44:57
Many times they can't operate in, in, in that case.
45:01
Um, if however, there's a nice fat plane between
45:04
the SMV and SMA and the pancreatic mass,
45:07
then a Whipple procedure can be performed.
45:11
So, uh, I want to thank everybody.
45:13
Uh, it was great, uh, giving you a talk.
45:16
Uh, my name is David Sarnia again.
45:18
Uh, my email is d.sarnia@northwell.edu
45:22
or my personal one is ids1@hotmail.com.
45:27
My cell number is 9 1 7.
45:29
6 4 5 2 4 7 3. And my Twitter
45:33
handle is David Sarney one.
45:35
And really, if you have any questions, uh, or you just
45:39
want to talk about residency, or if medical students
45:41
are listening to this and they are interested in
45:44
radiology, please feel free to, to reach out to me.
45:47
Radiology is a great field, and I'm
45:49
happy to, uh, to, to talk to anybody.
45:52
And again, thank you MRI Online and Dr. Collins
45:55
for inviting me for this, uh, exciting talk.
45:59
As we bring this to a close, I want to thank
46:01
Dr. Sarkany for this lecture, and thanks to all of
46:03
you for participating in our Noon Conference.
46:06
A reminder that this conference is
46:07
available on demand on MRIO nline.com.
46:11
In addition to all previous Noon Conferences, be sure
46:13
to join us again on Friday for a lecture from
46:16
Dr. Lori Deitte on ultrasound.
46:18
Can't-Miss Diagnosis.
46:21
You can register for that at MRIO nline.com and follow
46:24
us on social media at the MRI Online for updates
46:28
and reminders on upcoming Noon Conferences.
46:30
Thanks again, and have a great day.
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