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Wk 1, Case 2 - Review

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0:00

This was a pretty clear cut case of,

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of Graves disease and really one of the most severe cases I've seen.

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And I don't think anyone really had much of a problem with this case.

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The one thing that I,

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I did wanna point out on this is that in cases of Graves disease,

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it has a propensity to involve the inferior rectus and the medial rectus muscle.

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And this case it was involving all of the muscles and in fact,

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this very nicely shows the superior rectus muscle as well too.

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The one thing that I did want to to say is that, you know,

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all of you all I think got this case right,

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but really when we talk about the fellow level stuff, uh,

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when it comes to something like Graves' disease is that it is important, uh,

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in your report is to go ahead and mention whether or not the fat planes

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that are located at the orbital apex are intact. Because if a patient,

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uh, what Graves' disease can do is that it can give you a compressive optic

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neuropathy where the patients can begin to lose their vision.

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And what the surgeons can do is do an an,

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an orbital decompression where they actually go in and they can remove the

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borders of the, uh,

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bony margins of the optic nerve at the orbital apex.

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So they can remove part of the lamina capricia.

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They may could potentially remove the, uh, lateral wall of the gradle sphenoid.

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So the, uh, the, um, excuse me, I can't talk today, the, um,

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greater we of the sphenoid, which forms a lateral wall of the orbit.

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So I think it is important that you go ahead and mention that in your report.

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Now what I wanted to do too is, um, just give, uh, just a couple of,

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uh, real quick slides, um, on Graves' disease. So hold on,

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lemme just bring that up. Or thyroid ophthalm osteopathy.

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So just lemme bring that up here. So this is just another example of,

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um, thyroid ophthalm osteopathy. So this is an example of Grave's disease, uh,

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again, uh, very nicely showing the medial rectus, the inferior rectus,

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superior rectus and lateral rectus. Now, when you do look at Graves disease,

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realize the muscles also enhance with contrast.

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And the classic thing that was initially described with Graves disease is that

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you can have abnormal enhancement here of the muscle belly with relative sparing

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of the tendons. So when the muscles do attach to the,

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have their tendons insertion along the sclera, uh,

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just realize that in general the tendons tend not to

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tend not to be involved. So here's another example here.

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This is actually comparing thyroid ophthalm osteopathy with pseudotumor.

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So this is the classic case of thyroid pathy.

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You can see the involvement is involved in the muscle belly.

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But then when we look at the pseudotumor,

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when it comes to myo acidic forms of pseudotumor,

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we'll talk about pseudotumor a little bit later,

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but when you have this form that actually involves the muscles, in theory,

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the muscle tendon is gonna be enlarged and involved where it's relatively spared

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in, in thyroid pathy. The other thing, clinically, it's, it's,

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it's pretty s much easier clinically to separate between pseudo two and

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Thyroid pathy. So if you did see a patient with thyroid pathy,

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these patients tend not to have orbital pain.

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They do have proptosis as is seen here,

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but in pseudotumor they tend to have a lot of retrobulbar pain.

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So from a clinical standpoint, you know, it's, it's relatively easy to,

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to differentiate between pseudotumor and thyroid Pathy.

Report

Patient History
Edema. Graves disease.

Findings
Contrast-enhanced CT of the orbits is strikingly abnormal. There is diffuse bilateral enlargement of multiple extraocular muscles which include the inferior rectus, medial rectus and superior rectus muscles. There is also enlargement of the bilateral rectus, superior oblique and inferior oblique muscles. There is diffuse enhancement of many of the muscles with areas of low attenuation likely representing mucopolysaccharide infiltration. The enlarged extraocular muscles are resulting in substantial proptosis. There is loss of the perineural fat surrounding the optic nerve at the orbital apex suggestive of optic nerve compression. These findings are characteristic for thyroid ophthalmopathy due to Graves disease.

Visualized portion of the brain appears to be within normal limits. Visualized portion of the paranasal sinuses are well developed and well aerated. The lamina papyracea are intact.

Conclusions
1. Diffuse enlargement of all of the extraocular muscles consistent with a thyroid ophthalmopathy due to Graves disease.
2. Loss of perineural fat surrounding the optic nerve at the orbital apex suggestive of optic nerve compression by the diffusely enlarged muscles.
3. Severe proptosis.

Case Discussion

Faculty

David M Yousem, MD, MBA

Professor of Radiology, Vice Chairman and Associate Dean

Johns Hopkins University

Suresh K Mukherji, MD, FACR, MBA

Clinical Professor, University of Illinois & Rutgers University. Faculty, Michigan State University. Director Head & Neck Radiology, ProScan Imaging

Tags

Neuroradiology

Head and Neck

CT