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Oropharynx - Lymphadenopathy and HPV-Related SCC

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Hello, everyone.

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Dr. Sidney Levy here, continuing our

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discussion of the diagnosis and staging

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of oropharyngeal squamous cell malignancy.

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This is our sample right palatine tonsillar

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malignancy, which we've been looking at.

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And I would like to discuss how these

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tumors drain to regional lymph nodes.

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Palatine tonsillar tumors have a

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tendency to drain to the ipsilateral or

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sometimes bilateral level 2 lymph nodes.

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As these tumors may be human papillomavirus

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positive or negative, the morphology

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of lymph nodes can change as well.

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If the tumor is a human papillomavirus positive

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tumor, the morphology tends to be more cystic,

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whereas if it's negative,

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then it tends to be more solid and heterogeneous.

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If there is a cystic lymph node in this region of the

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neck, it's very important, uh, not to mistake it for

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a benign second branchial cleft cyst in the adult.

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And sometimes, quite often, it is necessary to sample

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the lymph node to confirm whether it is indeed a

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necrotic cystic lymph node or a benign branchial

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cleft cyst, as the two can look quite similar.

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In human papillomavirus positive disease, sometimes

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the lymph node will be the first indication

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that there is in fact a palatine tonsillar tumor,

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as the primary tumour may be too small

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to appreciate either clinically or on imaging.

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So it's very important that if there is an isolated

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lymph node within the neck, particularly in the

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region of level 2, that it be fully investigated

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to exclude a nodal metastasis and not dismissed

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as a benign second branchial cleft cyst.

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It is worth noting that the patient demographic

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for human papillomavirus positive disease is

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younger and often not associated with traditional

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risk factors such as smoking or alcohol.

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So you may have patients in their thirties who

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present with an isolated level 2 lymph node.

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which is cystic or necrotic.

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And this needs to be fully investigated, not dismissed

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as a brachial cleft cyst, and a thorough search

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needs to be made for a primary tumor in the tonsillar

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region, which may be subcentimeter or even smaller.

Report

Description

Faculty

Sidney Levy, PhD, MBBS

Radiologist and Nuclear Medicine Specialist

I-MED

Tags

Oral Cavity/Oropharynx

Neuroradiology

Neuro

Neoplastic

MRI

Head and Neck