Interactive Transcript
0:03
Hello and welcome to Case Crunch Rapid Case
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Review for the core exam hosted by Medality.
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In its rapid-fire format, faculty will show
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key images and you'll respond with the most
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likely diagnosis via the live polling feature.
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After a quick answer explanation, it's onto the
0:19
next case. Recording of all of these live board
0:22
prep videos will be available starting next week.
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Sign up for your free account
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now to have your access secured.
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Today, we're honored to welcome Dr. Elizabeth Hawk
0:32
for a nuclear medicine board prep case review.
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Dr. Hawk is a physician-scientist with dual board
0:37
certification in radiology and nuclear medicine.
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We are thrilled she's here
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today to lead us in this case.
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Questions will be covered at the end of
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time allows, so please remember to use the Q&A
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feature to submit any of your questions.
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And with that, we are ready
0:53
to begin today's board review.
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Dr. Hawk, please take it from here.
0:58
Alright, everyone. I am absolutely thrilled to be
1:01
doing your nuclear medicine case review
1:03
for the ABR core exam this evening.
1:06
Um, just a couple of disclosures.
1:07
Obviously, I'm not gonna be talking about anything
1:09
AI-related this evening, although I'd love to,
1:12
um, perhaps we'll save that for another day.
1:15
So what will we cover today over
1:16
the course of the next hour?
1:19
Nuclear medicine is my favorite
1:21
subspecialty of imaging because it really
1:23
does cover the entire body, head to toe.
1:26
Now, when I normally do a board review case
1:28
style, it's six hours for my UCSD residents.
1:31
Um, and then we can be more comprehensive and, and
1:33
cover sort of all the different things you could see.
1:36
But for tonight, we only have one hour, so it's
1:38
gonna be sort of a rapid-fire, uh, tour through the
1:41
human body, um, with all things nuclear medicine.
1:44
Now, if you're studying for the core exam, uh, I'd be
1:46
remiss if I didn't recommend that you review things
1:48
like radioactivity, radiopharmaceuticals, um, your
1:52
AU and radioisotope safety and hot lab pictures.
1:55
Um, but for tonight, we're not gonna be covering that.
1:57
Uh, what we will do is cover a lot of image
1:59
rich and case-based questions, um, broken
2:03
down, uh, the following four questions on
2:05
PET/CT and then two CNS/MSK and so on.
2:08
Um, I hope you enjoy it and, uh, look forward to
2:11
answering any questions at the end, time permitting.
2:14
So let's start with case one.
2:16
We have a 47-year-old woman
2:18
presenting for breast cancer staging.
2:21
I'll leave a few minutes on this image to
2:23
let you familiarize yourself with
2:25
it, and then we'll move on to the question.
2:30
So, finding annotated by the arrow in this image is
2:36
go ahead and give me your best multiple choice answer.
2:45
We'll give a few moments for everyone
2:47
to, uh, share their thoughts, enter their
2:50
poll, and see how it all turned out.
3:02
See that we've closed and most people said
3:04
metastatic internal mammary lymph node.
3:07
All right, let's, let's break this down a
3:10
little bit and talk about what's going on.
3:14
So in the answer, the answer is
3:15
actually an imaging artifact.
3:17
And this is a really, really important
3:19
thing that I want all of you to recognize.
3:20
Let's go through the case question
3:22
by question panel by panel.
3:23
So the first one is just a MIP showing
3:25
that there is an obvious hypermetabolic
3:27
thing in the region of the mediastinum.
3:30
Uh, now in panel A we have our
3:32
non-contrast-enhanced CT.
3:34
And you can see here that there's a super dense
3:38
thing there where the arrow's pointing to, and
3:40
what that actually is, is that's contrast.
3:42
Entering into the circulatory system, and that looks
3:45
very, very hypermetabolic on the fused image, which is
3:48
panel C. On panel D, we've got our attenuation-corrected
3:52
image, and you can see it still looks very, very bright.
3:55
But panel E, and this is the crux of the question,
3:58
is a non-attenuation-corrected image, meaning
4:01
that it's no longer there, it goes away on the
4:03
non-attenuation-correction image. If you think
4:06
about it, the background of the physics is
4:08
uh, we use attenuation correction or CT images to
4:12
tell the machine and the detectors what the path of
4:16
the signal had to go through to get to the detector.
4:19
So if it sees something super, super
4:20
dense like bone or metal or contrast or
4:23
calcification, it's gonna turn up that signal.
4:27
It thinks that that particle must have had to
4:29
go through something very, very dense to get to
4:31
the detector, and in this case, it's contrast.
4:34
Contrast is very, very dense.
4:35
So it's very important to, to remember that
4:38
this is an attenuation correction artifact,
4:40
that that's not a hypermetabolic lymph node.
4:43
And the crux of the, the question lies on recognizing
4:46
that E is the non-attenuation corrected image.
4:49
All right, let's move on.
4:54
Case two, the cause of this artifact.
4:56
So I'm gonna go ahead and tell you this is an artifact.
4:58
Go ahead, familiarize yourself with these images.
5:07
And let's go on to the question,
5:08
what is the cause of this artifact?
5:20
What do our answers say?
5:22
So some people say photo-multiplier tube.
5:24
Some people say motion.
5:25
Some failure in bed position and
5:27
some have failed CT detector.
5:28
So a little bit of each.
5:29
Um, and those of you that said, uh,
5:32
patient motion are absolutely correct.
5:34
So the most important thing to think about on
5:36
this one is that this artifact presents
5:39
across all the different imaging modalities.
5:42
So it's a PET artifact and it's a CT
5:46
artifact, and it's a fused image artifact.
5:48
Now, if it were a failure in the bed
5:50
position or just one of the individual
5:52
imaging modalities, we'd see it on.
5:54
One but not the other.
5:56
So you'd see it maybe on the PET 'cause the
5:57
PET is taken in bed positions, but not the CT
6:00
because we don't use bed positions for the CT.
6:02
Um, motion is a really common problem that
6:04
we see all the time and usually the most
6:07
problematic area is around the diaphragm.
6:09
'Cause even if the patient's holding still, they're
6:11
still breathing or hopefully they're still breathing.
6:13
Um, and that motion caused by the diaphragm
6:16
going up and down often causes the
6:18
hepatic dome to have a phantom
6:20
or a floating, um, look to it.
6:23
Uh, and it is very, very confusing when we're
6:25
trying to stage tricky things like pulmonary
6:27
nodules at the base of the lungs or, um,
6:29
subtle hepatic lesions in the hepatic dome.
6:31
So really important to recognize that
6:33
this goes across PET and CT images.
6:35
So it's gotta be a problem with the patient, not
6:38
necessarily the equipment on one side or the other.
6:41
All right, moving on.
6:46
Case number three.
6:49
So for this case, I want you to assume that
6:51
this is the same patient imaged four times,
6:53
and I'll show the question on the next slide.
7:00
So here's the question.
7:01
You don't necessarily need the images for the question,
7:04
but I like to have images in my practice questions.
7:17
I know it's a lot of words.
7:18
Sometimes it's hard to work through the words, but
7:21
questions like this will come up over the course of
7:23
the core exam, and it's important to stay sharp and
7:25
resilient and try and wade your way through the words.
7:35
Let's see what people said.
7:36
Great.
7:37
So you guys almost all got this question right?
7:39
The same patient can have highly variable myocardial
7:42
uptake from scan to scan, and, uh, that's super important
7:46
to remember, um, because that, oops, that patient, uh.
7:53
Could present at multiple times, depending on
7:55
diet, depending on many, many different factors.
7:58
Um, the myocardium will look very, very different from
8:00
scan to scan, and it doesn't mean that there's ischemia
8:03
or neoplastic involvement in the heart or pericardium.
8:06
It's just that the heart looks very
8:07
variable across different scans.
8:09
All right, moving on, case number four.
8:13
So this is a 64-year-old male with prostate cancer.
8:20
Let's move on to your question.
8:24
Appearance of the bones is most consistent with,
8:28
and I'll go back to the image if that helps you.
8:41
Let's see what you guys had to say.
8:43
So most people said widespread
8:44
osseous metastatic disease.
8:46
A couple good responses to therapy.
8:48
No one thought it was radiation.
8:49
A couple people thought it was normal.
8:51
So let's see what the answer is.
8:54
The answer is that it's a good response to therapy.
8:57
And let's go back to the image
8:59
to just take a look at why.
9:01
So if you look at this image, the bones look
9:04
diffusely bright, right?
9:06
There are, there's bright bones all over.
9:08
Now, right away you think this could be
9:09
widespread osseous metastatic disease, or you
9:12
think, okay, maybe the patient is receiving
9:15
G-CSF or some kind of marrow stimulation therapy.
9:19
So when I'm kind of stuck in that decision
9:22
point, I always look to the spleen.
9:24
Because if the spleen is also very, very bright
9:26
in a PET CT, um, you know that that marrow system,
9:31
that hematopoietic system is ramped up in responding
9:34
to the therapy, which in this case was G-CSF,
9:37
'cause the patient was very, very neutropenic.
9:39
Now if the bones had been diffusely
9:41
hypermetabolic, but the spleen wasn't, uh,
9:44
then you start thinking of metastatic disease.
9:45
But in this case, there's renal
9:47
excretion, there's bladder excretion.
9:48
This is not a super scan, and the spleen is also bright.
9:51
So then I start thinking along the decision
9:53
making tree of, okay, this is a good response
9:55
to therapy, and the therapy was probably
9:57
G-CSF or some kind of marrow stimulation.
10:00
It's a little bit of a tricky question, but, um,
10:03
important to really think about the whole picture
10:06
and why I'm giving you that picture and what
10:08
organs are bright that necessarily shouldn't be.
10:11
All right, moving on case five 37-year-old male
10:15
history of trauma and we're imaging with TNIC, DTPA
10:22
can almost guarantee you'll see a
10:23
question like this on the core exam.
10:25
It's one of those sort of classic
10:27
do not miss type questions.
10:29
Let's go to the, uh, actual question.
10:43
Let's see what people said.
10:44
Some people say absence of intracranial flow.
10:47
A few people say presence of intracranial
10:49
flow, and some people say, "terant."
10:51
So the reason why I chose to show you this.
10:54
And the reason why I specifically tell you
10:56
that the patient's image with TECHNETIUM 99 D
10:59
TPA A is 'cause you have to understand what
11:01
the radiotracer is and where it's going.
11:04
So some radiotracers will cross the blood-brain barrier
11:07
and go into the brain, and others do not cross the blood
11:11
brain barrier, and they do not go into the brain.
11:14
So this is actually present intracranial flow.
11:16
It's a normal brain scan for brain death,
11:19
and it's important to understand that
11:21
TECHNETIUM 99 DTPA doesn't go into the brain,
11:25
it doesn't cross the blood-brain barrier.
11:26
So what we're looking for here is not
11:29
radiotracer within the brain parenchyma.
11:31
We're looking for present radiotracer within
11:33
all the venous structures of the brain,
11:34
in this case, the sagittal sinus, and the
11:36
coronal sinus and the sigmoid sinuses.
11:39
So it's very, very important to really think
11:41
about which tracer you're using, whether
11:44
or not it crosses the blood-brain barrier.
11:45
And then whether or not it's a normal distribution.
11:47
And in this case, it was a negative brain
11:49
death exam or present intracranial flow.
11:52
Um, and it's a little bit sneaky 'cause
11:55
it does look empty, but it's important
11:56
to understand that radiotracer.
11:59
All right, let's move right along to the next case.
12:01
This is a 68-year-old female
12:02
with a history of memory loss.
12:06
This is the scan.
12:07
Let's move on to the question.
12:11
So the radiotracer used in this examination is, and I,
12:14
I hate these questions of what is this tracer question,
12:17
but try and see if you can put it all together.
12:19
It's a little bit of a cutting edge neuro question.
12:24
I can go back to the image while we're waiting.
12:26
If you want.
12:30
A lot of it tends to look like alphabet soup.
12:41
So most of you got this right?
12:43
That's great.
12:43
This is PET beta-amyloid or an Amyloid scan.
12:46
Uh.
12:48
It's really important to recognize what a normal
12:50
and what an abnormal amyloid scan looks like.
12:52
So this is a scan that we do specifically
12:54
to look for amyloid plaques
12:56
in the setting of Alzheimer's disease.
12:58
And I kind of snuck a second bonus
13:00
question or a bonus teaching case in here.
13:02
Um, I've got a normal example on the right hand
13:05
side and an abnormal example on the left side.
13:08
The radio tracer normally goes to all the white
13:10
matter and produces that beautiful sort of spider-like
13:12
outline of the white matter in a normal distribution.
13:16
If the case is abnormal or positive for amyloid,
13:18
you see these clustered bits of radiotracer
13:21
all over the cortex where it shouldn't be.
13:23
So good job on that case.
13:26
All right, moving right along to case seven.
13:29
We've got a 77-year-old male with a history of prostate cancer.
13:33
Here is the scan.
13:36
I know a lot of you are thinking right away.
13:38
I know this, I know this case.
13:40
I've seen it before.
13:40
Let's see what the question is though.
13:44
So a lot of you probably knew what the case was.
13:46
It's classic, but a lot of board questions
13:49
like to take you to that next level
13:50
and see if you understand the tracer.
14:02
Let's see what people said.
14:04
Chemosorption.
14:05
Near the osteoblast is what most of you said, and
14:09
the answer is chemosorption near the osteoblast.
14:12
So this is your classic MDP bone scan
14:14
and, uh, it's a bonus teaching case.
14:16
I tried to cover as much ground as I could in the hour.
14:18
This is a super scan, so you don't see the
14:21
kidneys or the urinary bladder very much.
14:23
You see a little bit of bladder, but
14:24
this is what we would call diffuse
14:26
widespread osseous metastatic disease.
14:28
And a lot of you would recognize the super
14:30
scan right away, but what I really want
14:31
you to understand is how MDP accumulates.
14:34
Um, and in this case, this radiotracer, um, goes
14:37
on the chemosorptive end of the osteoblastic
14:40
activity, which is why it's really, really great
14:43
at visualizing sclerotic metastatic disease
14:45
and not so much lytic metastatic disease.
14:47
Metastatic.
14:49
Great job.
14:51
All right, next case.
14:51
68-year-old female with a history of breast
14:54
cancer coming in for a staging PET CT.
15:02
Let's go to the question.
15:15
and see what everyone says.
15:16
Great.
15:17
So most of you are saying osteopenia,
15:19
which is the correct answer.
15:23
And what are we looking at?
15:24
What is this?
15:24
This is the classic H or Honda sign.
15:28
Um, I like to think of it as a butterfly, but
15:30
you can think of it as whatever you like, but
15:32
it's classic for sacral insufficiency fractures.
15:35
Um, a lot of these patients are also on different
15:38
therapies that, uh, can lead to osteopenia
15:42
in the bones, um, and then they can develop sacral
15:45
insufficiency or vertebral body insufficiency
15:47
or other insufficiency fractures over time.
15:49
Um, very, very important to recognize that
15:51
this is not usually metastatic disease.
15:54
Uh, now if we were really pressed, could
15:55
there be a metastasis hiding in there?
15:58
Sure, absolutely.
15:59
Um, can a fracture due to trauma also be hypermetabolic?
16:03
Yeah, but it's usually not
16:04
bilateral in a pattern like this.
16:06
Um, and we don't see any signs of osteo erosion
16:09
or, um, sacroiliitis to indicate infection.
16:12
So this is really a, a classic sign.
16:15
The Honda sign or the H that's.
16:16
Related to a sacral insufficiency
16:18
fracture, um, which is osteopenia.
16:21
Okay.
16:22
Case nine 28-year-old presenting for evaluation.
16:28
So I want you to look at this image,
16:29
think about what we might be imaging,
16:34
what we might be using to image.
16:37
And this is the question.
16:50
I've got some six hours, some 13 hours, a
16:54
couple eight days, and a couple 110 minutes.
16:57
Okay, great.
16:59
So the tricky thing about this is some things on
17:03
the core you just need to memorize and I, I hate
17:06
that, but when I was studying for the core, I had.
17:08
Piles and piles of flashcards 'cause some
17:10
things you can't think your way through.
17:12
Now, what makes, uh, this question kind
17:14
of fun or fun for me at least, is that
17:17
you have to take it a step further.
17:18
You can't just recognize the radio tracer.
17:19
You kind of have to recognize which one.
17:21
Right?
17:22
So the answer is eight days because this is I-131.
17:28
Now some of you said 13 hours, uh, because
17:31
you recognized that this was an iodine scan.
17:34
Now you've gotta take it one step further and say, well,
17:36
this is a low dose or a high dose thing, and we can see
17:39
a really, really beautiful star artifact on the neck.
17:42
And that star artifact is created when the
17:45
radiotracer has such a strong energy that it's
17:47
penetrating the collimators, um, and bleeding out,
17:51
you know, beyond where it's supposed to be imaged.
17:53
And that creates that star, um,
17:54
artifact when we're imaging it.
17:55
So we know we're dealing with
17:56
something that's very high dose.
17:58
Something that's very high energy, which means
18:00
this is an I-131 exam, not an I-123 exam.
18:04
And then unfortunately, you just need
18:06
to have your half-lives memorized.
18:07
Um, so that, for those of you that said
18:09
six, that's the Technetium-99m half-life and
18:12
110 minutes, of course, is our workhorse
18:15
in oncologic imaging, F-18 for PET imaging.
18:18
Um, but the important thing to know is that this must
18:20
be a high dose exam and that this is an I-9 exam.
18:23
So eight hours is the right answer.
18:28
Case 10.
18:31
We're staying with our head and
18:33
neck imaging as we tour the body.
18:35
This is the case.
18:36
Let's look at the question.
18:53
All right, so what do we have?
18:54
It looks like a lot of people went for
18:56
a bone pain, vomiting, and depression.
18:58
Some people, uh, voted for B muscle spasm, abnormal
19:02
heart rate, tingly fingers, no votes for C. That's good.
19:05
And uh, just a couple votes for
19:07
sweating, nervousness, and insomnia.
19:10
So, one of the things that I love
19:13
the most about nuclear medicine is.
19:16
We still very much practice patient care and
19:19
the art of, um, medicine with our patients.
19:22
And symptoms matter and a lot of times we get
19:24
consulted to talk about cases and think through
19:27
things, um, and the clinical history and the
19:29
patient symptoms become very, very important.
19:32
Um, now this is a classic parathyroid case.
19:34
We're looking at, uh, parathyroid adenoma.
19:37
And a lot of you probably recognize that when you first
19:39
saw the image, but the question really lies in, well,
19:42
do you know what hyperparathyroidism presents us and.
19:45
Question, uh, answer A has all the sort of
19:48
classic symptoms of hyperparathyroidism.
19:51
B is hypoparathyroidism, uh, C and D,
19:56
uh, deal with hyper- and hypothyroidism.
19:58
So, uh, parathyroid versus thyroid.
20:01
Um, and then it's important to know hyper versus hypo.
20:05
Uh, a lot of these images, and I've annotated them,
20:08
are from a book Metler Essentials of Nuclear Medicine.
20:11
Um, if I had my wish for all of you, it would
20:14
be that you read that book cover to cover.
20:15
It is an excellent book for studying
20:18
for the core for nuclear medicine.
20:19
If you feel like you need a little bit of extra, um,
20:22
material, and all of this is usually covered in there.
20:28
Alright, case 11.
20:30
49-year-old male, history of testicular
20:33
cancer, presenting for staging evaluation,
20:36
and we've got these interesting findings.
20:44
Let's move on to the question.
20:57
What did people say?
20:59
A little bit all over the place.
21:00
So we've got some votes for metastatic
21:02
disease, uh, some for vaccination, some
21:05
for infections, some for foreign body.
21:08
I love this case.
21:09
My UCST residents know that I love showing this case,
21:13
uh, when I do board review because every now and
21:15
then, um, they just like to throw in something fun.
21:18
And this is a fun case.
21:19
I think it's a very interesting case, um,
21:21
and something that's very, very practical.
21:24
I. So what is this?
21:25
This is a foreign body, and this is tattoo ink
21:27
as a foreign body, um, more common than we think
21:30
it is, and more practical than we think it is.
21:32
Um, now if you look back at the case,
21:34
there were bilateral axillary lymph nodes.
21:36
Right now, can you get hypermetabolic, axillary
21:39
lymph nodes in the setting of vaccination?
21:40
Yes, but almost always they're unilateral
21:43
and some, unless someone got.
21:45
Shot in the same arm at the same time that had
21:47
the same kind of reaction to the axillary lymph
21:49
nodes, which would be, um, very serendipitous.
21:52
Um, could it be metastatic disease?
21:54
Sure, it, it could, but those lymph nodes were
21:56
pretty small and it was just in a very symmetric
21:59
and even distribution, which doesn't really,
22:02
um, fit the pattern of metastatic disease.
22:04
And could it be infection?
22:06
Yes.
22:06
But again, so perfectly symmetrical and bilateral,
22:10
um, in small lymph nodes that are not very enlarged.
22:12
Um, you're thinking something else.
22:15
Um, and in this case it's tattoo
22:16
ink, uh, which is a foreign body.
22:18
Um, it's not an infection, it's not an infected
22:20
tattoo, it's just that the ink particles can
22:23
get taken up if they go a little bit deeper.
22:25
Um, and they often get, uh,
22:27
taken up by the lymph system.
22:29
And can, uh, produce an inflammatory response
22:32
or, or hypermetabolic appearance on PET CT.
22:35
So sometimes it's important to think outside the
22:37
box and to really think through different patterns
22:40
of potential disease presentation and to just use
22:43
your general knowledge to sort of help you work
22:45
through why the other answers may not be correct.
22:50
All right.
22:50
Case 12.
22:51
I hate these, but inevitably they'll
22:55
probably show up on the exam.
22:57
So, um, it's a classic one.
23:01
And here's the question for you.
23:14
See what people said.
23:16
Wow, you guys are superstars.
23:18
Everyone said gallium now.
23:21
Don't feel bad if you said indium or sulfur colloid.
23:23
'Cause I almost always get these
23:25
wrong in my own practice questions.
23:27
Um, but this is gallium-67.
23:29
The important thing to think about is that the gallium
23:32
likes to image or, or label the lacrimal glands.
23:35
And you have that kind of classic,
23:36
almost panda face, uh, appearance.
23:40
In this case, it was a positive
23:41
sarcoidosis scan, I believe, from Mettler.
23:43
Um.
23:44
Think about liver and spleen, uh, when you're
23:47
thinking about sulfur colloid or indium-111.
23:50
Indium-111 loves a super, super, super hot spleen.
23:53
Um, go, um, flip through a textbook or some literature
23:57
and just familiarize yourself with the
24:00
look of how these different radio tracers appear.
24:03
Um, gallium is probably one of the most classic
24:05
because of that lacrimal gland appearance.
24:07
Um, so it's kind of the easiest to point out
24:09
out of the, uh, other ones in this group.
24:13
All right.
24:14
Moving along to the cardiac section
24:16
in our whirlwind tour of the body.
24:18
It's a 58-year-old male with a history of chest pain.
24:23
Here are your images.
24:24
We'll give you a minute here to
24:27
familiarize yourself with these.
24:34
There's a lot of different theory about how to
24:36
approach multiple choice, but some people say.
24:40
You should already see the answer or know what
24:42
they're getting at before you see the question.
24:43
And this is the case in this one.
24:45
Um, but here's the question nevertheless.
24:58
So most of you are saying
24:59
reversible anterior wall ischemia.
25:02
Um, a couple saying irreversible.
25:04
Irreversible scar.
25:06
Um, let's, let's walk ourselves through this answer.
25:11
So this is a reversible anterior wall ischemia.
25:15
Um, if we go back really quick just to the annotation,
25:17
you're gonna see lots of annotations when you take an
25:19
exam and everyone's kind of nervous and they're like, oh
25:21
my gosh, I don't know what all these letters stand for.
25:24
But just take a step back and think logically something
25:27
ends in an "s," it's probably gonna be your stress.
25:29
If something ends in an "R," it's
25:31
probably going to be your rest.
25:32
And if you can't figure out the rest of it, that's okay.
25:35
Um, but just try to think logically.
25:36
through different annotations 'cause.
25:38
Different weird annotations can show up.
25:40
Um, oftentimes there's what I call an
25:43
iatrogenic arrow or an arrow sign where
25:45
they like to point out what's going on.
25:47
And this is the case in this question.
25:50
Um, and just in case you're not used to looking
25:52
at these different, um, SPECT images, often they
25:55
provide this bullseye diagram that kind of shows
25:57
you a different perspective on what's going on.
26:00
And in this case, it's very
26:01
clearly labeled stress and rest.
26:03
So what you have is an area of photo or a defect.
26:07
In the stress imaging that then normalizes
26:10
on rest imaging, and that's a classic
26:12
pattern for something that's reversible.
26:14
So it's only present on stress, not present on rest.
26:18
Um, there's a lot of different
26:19
diagrams that you can look up.
26:21
Again, this one's from Mettler.
26:23
And you can memorize them for the parts of the
26:26
wall because it's very, very important to know
26:28
your coronary artery anatomy and your wall anatomy.
26:31
So understanding which part is anterior,
26:34
inferior, septal, and lateral is gonna
26:36
be key to getting questions like this.
26:38
Correct.
26:39
So spend some time with the bullseye diagram.
26:41
Um, just familiarize yourself
26:43
with the anatomy and the terms.
26:45
Um, and then just.
26:48
Kind of take a breath when you see annotations
26:50
or presentations that you don't know and
26:52
allow your logical brain to work through them.
26:54
I know it's easier said than done under
26:56
a stressful situation, but usually
26:57
you can work through what's going on.
26:59
So in this case, this is
27:00
reversible anterior wall ischemia.
27:04
All right, moving on
27:07
Case 1480: 2-year-old woman presenting
27:09
for cardiac clearance evaluation.
27:12
A lot of these cases are for pre-op clearance,
27:15
so I'll give you a few minutes with this image.
27:18
Familiarize yourself with it.
27:27
And let's go to the question
27:40
and let's see what people say, a
27:42
little bit all over the board.
27:43
Some people say acute ischemia.
27:45
Some people say hibernating myocardium.
27:47
Some people say an aneurysm.
27:48
Some people say hypertrophic cardiomyopathy.
27:52
Maybe this isn't the best question in the
27:54
world because there are a lot of sort of
27:56
potential, um, answers or potential things
27:59
that could be going on at the same time.
28:01
But in this case, this is a
28:02
super classic sort of anterior
28:06
image of a left ventricular apical aneurysm.
28:09
Now remember when we say aneurysm, it
28:10
doesn't necessarily mean it's an aortic
28:12
aneurysm or a, a different vessel.
28:15
It could be an apical aneurysm.
28:17
Um, and in this case it's not, uh, acute, uh, ischemia,
28:20
because it's not, doesn't change on rest and stress.
28:24
Um, we can't really tell if it's hypo-, hibernating,
28:26
myocardium or not because we don't have the viability
28:28
images to be able to see if that's the case.
28:32
Um.
28:32
Could this person have hypertrophic cardiomyopathy,
28:35
underlying, maybe, but usually you see sort
28:37
of a diffusely enlarged ventricle without
28:40
this giant aneurysmal defect at the apex.
28:43
So it's probably not what we're
28:44
trying to get at for this case.
28:46
In this case, this is the really classic left
28:48
ventricular apical aneurysm, and it'd be really
28:50
important to, to recognize this and let them know
28:52
about this prior to, uh, cardiac clinics for surgery.
28:56
All right, case 15.
29:01
On to, uh, pulmonary.
29:08
So again, look at these images.
29:11
Uh, you can probably already tell what type of question
29:14
is gonna be written with these types of findings.
29:17
So think in your head, what would she
29:19
ask if she was writing a question?
29:21
And
29:24
here's our question.
29:36
Let's see what everyone says.
29:39
So a lot of people are saying large pulmonary embolism.
29:42
Some people are saying congenital defect.
29:44
Some people are saying neoplasm, and
29:46
some people are saying infection.
29:48
Nope, no one's saying infection.
29:49
That's great.
29:50
All right, so what are we dealing with in this case?
29:53
Let's talk about it.
29:54
So the answer is actually neoplasm.
29:56
This is a case of lung cancer and a lot of
30:00
you're gonna say right away, whoa, wait a minute.
30:02
Why isn't this a large pulmonary
30:03
embolism and a very, very large pulmonary
30:06
embolism that takes out the entire lung?
30:08
Yes, that could happen.
30:09
That could create that massive perfusion defect.
30:12
But the reason why this case is put
30:14
together in this manner is because we're
30:16
looking at a large mass on the chest x-ray.
30:20
A mass that's big enough that we can actually
30:22
just see it on the single view radiograph.
30:25
Um, if it were a very, very large pulmonary
30:27
embolism, we wouldn't necessarily see a mass there.
30:31
Um, but in this case, there's a large
30:33
mass in this region, which, um, ultimately
30:36
constricts the left pulmonary artery and
30:38
results in absence of flow to the left.
30:41
He has, and just to walk through it completely.
30:44
Our ventilation images are, are normal.
30:46
That's pretty uniform ventilation.
30:48
Depending on the position of the patient,
30:50
sometimes there'll be a little bit of
30:51
decreased ventilation at the apices, but that's
30:54
sort of to be expected with the technique.
30:56
Perfusion image shows complete absence
30:58
of perfusion to the left hemithorax, and
31:01
then we move down to our radiograph.
31:02
Remember, in order for a VQ scan to be, um,
31:06
technically sensitive and specific enough
31:09
to be used, we need a chest radiograph,
31:11
uh, in close proximity to the VQ scan.
31:15
In this case, you really need to scrutinize that
31:16
radiograph, and you can see that very, very large
31:18
mass, which pushes us toward the most likely answer of
31:22
being a neoplasm rather than a large pulmonary embolism.
31:27
All right.
31:28
I know that's a little bit tricky, but I just
31:30
want you guys to not jump at the very, very
31:32
obvious nuclear medicine finding, but to use
31:35
all of the information that's given to you,
31:37
and in this case, the chest radiograph is key.
31:43
Here is another bit of an Ant Mini.
31:50
We'll spend a few moments on this image just
31:53
so you guys can get your lay of the land,
32:00
and let's go to.
32:13
Let's see what you guys thought.
32:14
We're a little bit all over the place.
32:16
Uh, a little bit of votes for everything.
32:18
Um, this one's a hard one.
32:19
It's a hard one to tease apart
32:21
piece by piece.
32:21
Piece by piece.
32:23
Um, some people may think, uh,
32:25
free protect something like that.
32:28
Um, some people may think, well, there's a
32:30
right to left shunt, but we're not really
32:31
seeing the brain or, or other things like that.
32:33
Um, what this is, is this underlying
32:36
pathology, and it is, um, hepatic steatosis.
32:39
So this is a classic, uh, ventilation image for a
32:42
pulmonary exam, and it was done with Xenon-133.
32:45
And with Xenon-133, it's a well-known fact
32:48
that it actually will accumulate in the
32:50
liver, in the setting of hepatic steatosis.
32:53
It's kind of one of those T-minis that you
32:54
just need to see, know, learn, understand.
32:58
Um, this is because xenon is soluble in fat.
33:01
Uh, so we see it in hepatic steatosis.
33:05
Uh, if you wanna read more about this or see
33:07
this case in particular, it's in Mettler as well.
33:09
Um, it's one of those ones that I kind of just had
33:11
to learn when I was studying for boards as well.
33:14
But a really good aunt, many for all of you guys to see.
33:19
All right, here's another one we're moving on to
33:22
GI. Uh, for me, there's a lot I could have shown
33:26
you in GI. Uh, there's all sorts of things from
33:29
acute GI bleeds to tagged white blood cell scans
33:32
to Meckel's diverticulum, to all sorts of things.
33:35
But I only had two cases and when I was studying for
33:38
boards, what I struggled with the most was liver.
33:41
I know about you, but I thought
33:42
the liver lesions were super hard.
33:44
So we're gonna do a couple liver questions.
33:46
This is a 37-year-old woman who had a liver lesion
33:50
and they're trying to figure out what it is, so go
33:52
ahead and familiarize yourself with the images.
33:59
Let's see what kind of question we're gonna ask.
34:12
See what you all said.
34:14
We've got a few votes for everything.
34:16
Most of you are calling this a hemangioma.
34:19
Um, let's see what we have.
34:23
So this is indeed a hepatic hemangioma.
34:25
Good job.
34:26
So what we have first are, uh,
34:29
the technetium-99 sulfur colloid scan.
34:31
Um, and we've got a cold defect where that lesion is.
34:34
So it doesn't take up sulfur colloid, or it
34:36
takes up less than the surrounding hepatic tissue.
34:39
Um, then you've got your, um, tagged red blood
34:41
cell scan, and you know that that's a red blood
34:43
cell scan in panel B in the bottom panel.
34:46
'Cause you can see all the vessels
34:47
and the heart is lighting up.
34:49
Um, it looks like an angiogram
34:51
or a very unclear angiogram.
34:53
Um, so you know that that's
34:54
a tagged red blood cell scan.
34:55
So that lesion is just lighting up
34:57
on that tagged red blood cell scan.
34:59
Um, and then we've got our SPECT-CT.
35:02
So we've got a CT to go with that red blood cell
35:04
scan, and we've overlaid them on a fused image to
35:07
show that that intense radiotracer localization in
35:10
the red blood cell scan localizes to that liver.
35:14
So you've got something that's cold on
35:15
your sulfur colloid scan and then hot
35:18
on your tagged red blood cell scan.
35:20
Um, and that's really classic for a hemangioma.
35:23
It's a great way to sort of work up that lesion.
35:25
Um, before MRI was widely popular.
35:28
Nuclear medicine will really, the experts in this and
35:30
uh, a lot of these questions tend to still show up.
35:35
Show.
35:35
All right, let's do one more liver question.
35:37
This is a 37-year-old woman with a liver lesion.
35:40
Let's see what you guys say.
35:47
Here's our question.
35:58
Let's see what you guys thought.
35:59
A few.
36:00
Hepatocellular carcinomas.
36:02
One vote for mets, uh, a bunch of FNH.
36:05
Great.
36:06
And no one voted for angioma.
36:07
Of course, I wouldn't show you two.
36:08
Angios in a row.
36:09
That would be a little bit cruel.
36:11
So the answer is FNH.
36:14
So first we've got our just standard
36:15
contrast-enhanced CT of the liver.
36:18
Um, we gave you a little bit of a
36:19
hint because this is a young woman.
36:22
Uh, if I really wanted to give you an extra
36:23
hint, I would've said on oral contraceptives.
36:26
Um, and this is a well-defined focal low-density lesion.
36:31
Sort of classic rounded appearance.
36:33
And then we have a liver spleen scan, right?
36:35
Your sulfur colloid scan.
36:37
Um, and that scan shows, uh, similar distribution, uh,
36:43
in the region of the, in the region of the liver.
36:46
So there's normal, we really don't see
36:48
any uptake in the sulfur colloid scan.
36:50
So it's a discrepancy or a mismatch.
36:53
Um, and it's really, really classic
36:54
for FNH or focal nodular hyperplasia.
36:57
Is a prime consideration.
36:58
It's, um, really, really important that you
37:00
don't send this, um, young woman down the path of
37:04
hepatocellular carcinoma or metastatic disease.
37:08
Um, this is just a classic FNH type case.
37:14
All right, let's move on to renal.
37:19
Renal transplant tends to be a little extra
37:21
tricky, uh, beyond just the renal case.
37:24
So since we only have two, I thought
37:25
I'd give you a transplant case.
37:27
You can go ahead and familiarize
37:28
yourself with these images
37:36
and let's look at the question.
37:47
So most of you are saying ATM or acute
37:50
tubular necrosis, which is great.
37:52
These questions can be a little tricky.
37:55
Um, and sometimes just the fact that
37:57
it's a renal transplant scares us a
37:59
little bit 'cause it's unfamiliar.
38:01
And although many of you have seen
38:02
probably a lot of renal cases only, um.
38:05
Handful of transplant cases
38:07
come across us in our training.
38:09
Um, but this is really, really classic,
38:10
uh, ATN or acute tubular necrosis.
38:13
So we've got our anterior perfusion images,
38:15
that's a right pelvic transplant kidney
38:18
or right iliac fossa transplant kidney.
38:21
And we've got normal perfusion.
38:23
Initially, we've got our 1, 2, 3, 4 second flows.
38:26
Um.
38:27
Then our renogram show sort of this
38:29
increasing sort of growing parenchymal
38:32
activity over the next, um, up to 45 minutes.
38:35
We've imaged this patient.
38:37
And so the radiotracer is just kind of sitting
38:39
in the renal cortex and just staying there.
38:42
Um, and that's really, really classic for acute
38:45
tubular necrosis, which is a very important diagnosis
38:48
to recognize in the setting of transplant medicine.
38:52
Um, a leak, usually you would've seen progressive
38:54
pooling, uh, in the pelvis from, uh, urine
38:58
that's leaked out of the renal collecting system.
39:00
It's a very common complication in renal transplant.
39:03
Or sometimes you'll see leaks in post
39:05
cholecystectomy cases for bile leaks.
39:07
Um, this isn't a normal exam 'cause you
39:09
shouldn't have that persistent sort of
39:10
perfusion that's just growing over time.
39:13
Um, and it's not chronic rejection.
39:16
It's acute tubular necrosis in this case.
39:21
One more renal case for us.
39:24
Evaluate worsening renal function,
39:27
really common clinical history.
39:31
There's a lot going on in the slide, so
39:33
I'll stay some extra minutes to let you
39:36
really process everything that's going on.
39:43
I feel questions like this, especially toward
39:45
the middle or the end of the exam, are really
39:47
taxing when our brains are already a little
39:49
fried from being stressed out for so long.
39:52
And although they may be patterns and curves that
39:54
you're used to seeing, it's really important to
39:56
read all of the words that are labeled so that
39:59
you know exactly what it is you're dealing with.
40:01
'Cause this is a little bit out of the ordinary.
40:08
Let's move on to the question.
40:19
All right.
40:19
We've got a few votes for mechanical
40:21
obstruction, some for arterial stenosis.
40:23
No one fell for the venous stenosis strap
40:26
and one vote for pilo, and the answer is.
40:31
Arterial stenosis.
40:32
So, uh, a lot of times when you see these renal
40:34
exams, it's gonna be pre and post Lasix, right?
40:37
Uh, Lasix is the classic drug that kind of stimulates
40:40
the kidneys to give up the urine and push it through,
40:43
uh, the outlet, uh, and into the urinary bladder.
40:47
This is not a Lasix evaluation.
40:49
This is a captopril evaluation.
40:51
And captopril is the agent that we use
40:53
to evaluate for renal artery stenosis.
40:57
So these are classic mag three grams.
41:00
Um, pre captopril, uh, they're
41:03
slightly asymmetric activity, right?
41:05
If you look at those two curves
41:06
that are still up, the, uh,
41:08
right.
41:08
Kidney is struggling a little
41:10
bit more than the left kidney.
41:11
Um, but post-captopril, you get sort
41:14
of an exaggeration of what's going on.
41:16
Um, and then you get that marked abnormal retention
41:19
of radiotracer, um, activity in the right kidney.
41:23
It just kind of continues to retain radiotracer
41:26
and doesn't, doesn't let it go, and doesn't,
41:28
um, excrete it into the collecting system.
41:31
So this is a really, really classic case of, um.
41:36
Of, uh, renal artery stenosis.
41:38
And it's important to recognize even though those
41:39
slides are very, very busy, that you're dealing
41:41
with a captopril exam and not a Lasix exam.
41:46
All right, so we're gonna start wrapping up, um, and
41:49
I'll give you a few words of wisdom and how I would
41:53
love all of you to approach studying nuclear medicine.
41:56
Um, for the core.
41:58
Um, nuclear medicine, a lot of
41:59
people joke, it's unclear medicine.
42:02
You'll see lots of cases in the middle
42:04
of the test that look a little confusing
42:06
or just look like giant ink blobs.
42:09
Um, some people just say it looks
42:10
unclear because it's all fuzzy.
42:12
And, and that's true to some extent.
42:15
But what I love about nuclear medicine is it's
42:17
really just about common sense about thinking
42:19
through physiology and um, understanding how the
42:23
radiotracers interact with the human body and then
42:25
seeing what doesn't fit or what doesn't make sense.
42:28
And usually, you can work your way
42:29
through the questions that way.
42:30
Um, try to eliminate your obviously wrong distractors,
42:34
and then walk through the potential right answers, just
42:36
with your knowledge of the human body and physiology.
42:39
Uh, unfortunately, there are a few things that you
42:41
do have to memorize, and those are half-lives, um,
42:45
energies of radio tracers, and then a lot of the
42:48
stuff that we didn't cover today that has to do with
42:50
the regulatory requirements and the dose limits to
42:53
different parts of the body and things like that.
42:56
Um, I will say I've looked at a lot of different
42:59
board review, um, presentations over the months and
43:04
years over my training and my attending-hood, and
43:07
almost everyone builds their board reviews off of
43:09
MET One, which is the Essentials of Nuclear Medicine.
43:12
It's a great book.
43:13
It's, uh, fairly easy to read and all the
43:16
cases are ant-minis or classics that are
43:18
likely to show up in a testing scenario.
43:20
So, uh, I don't have any stake in the book.
43:22
Obviously, it's a conflict-free recommendation, but,
43:26
um, if you're looking for one fantastic source, uh,
43:29
Metler is supported as the go-to for nuclear medicine.
43:33
Um, so with that, good luck.
43:35
I will, uh, be happy to open it
43:36
up to questions, comments, uh.
43:40
Questions on other exam resources, whatever
43:42
you like, uh, open it up to the group.
43:47
Dr. Hawk, thank you so much
43:48
for that amazing case review.
43:50
That was awesome.
43:51
And, um, yeah, we will open up the floor for
43:54
any questions, so if you have questions, go
43:56
ahead and put them in that Q and A feature.
43:59
Dr. Hawk, I'm not sure if you're able to open it up on
44:01
your end to see we've got a question in there already.
44:04
I, yes, you can move it around so I can see it.
44:09
I see for case 19, how would chronic rejection appear?
44:14
Um, it depends on what, what, what we're looking at.
44:16
If it's really chronic, the
44:17
kidney just wouldn't be working.
44:18
Um, so the, the most classic chronic
44:20
cases, the kidney wouldn't be functioning.
44:22
There wouldn't be any uptake of radiotracer.
44:24
There wouldn't be any excretion of radiotracer.
44:27
Um, they could show you any spectrum of
44:30
acute to chronic.
44:31
But my guess is if they're showing you something
44:33
where it's cloudy and staying in the renal
44:35
cortex, it's gonna be a TN chronic rejection.
44:38
Is the kidney's just not working?
44:40
Um, like if we went back to that case and we
44:42
imaged up in the upper abdomen with the patient's
44:44
native kidneys that were no longer working, you
44:46
would just see no radiotracer there at all.
44:49
I hope that helps.
44:53
Any other questions from the group?
44:54
You guys are quiet.
44:57
Sometimes it takes a second, so we'll, we'll hold for
45:00
a couple, couple moments to see if any come flying in.
45:05
And also, I, I hope all of you, uh, follow Modality
45:08
online across their different social media outlets.
45:11
They've tagged me as well in this post.
45:13
If you wanna reach out and ask me additional
45:16
questions or connect in that space, I'm always happy.
45:19
To mentor students, encourage
45:20
students, and connect with students.
45:22
Boards are a super difficult and stressful time,
45:26
uh, and I know you guys all have a lot on your plate
45:29
and are trying to juggle a lot of things, uh, which
45:31
is why I'm really, really excited to partner with
45:34
Modality to sponsor some memberships to Modality.
45:37
So, um, please check out that info and, uh, hopefully
45:41
one of you that join me tonight will win a sponsored
45:44
membership to Modality that would make me really happy.
45:51
So nice of you, Dr. Hawk.
45:52
Really appreciate you paying it forward like that.
45:54
That's, that's awesome.
45:57
Let's see.
45:57
Do we have another question?
46:00
I will type an answer to that question.
46:02
All right.
46:03
Um, we can go ahead and wrap up if
46:05
anybody has any other questions.
46:07
Like Dr. Hawk said, uh, you can follow Medality
46:09
online and find her contact information there.
46:13
Thank you so much again, Dr. Hawk,
46:14
for this amazing case review.
46:16
It was awesome, and I hope everyone else enjoyed it.
46:19
And thank you so much for participating to our audience.
46:22
Thanks everyone.
46:24
Good luck.
46:26
Be sure to join us next Monday,
46:28
March 18th with Dr. Navid Raji.
46:30
Well, he will do a rapid review of MS & MSK cases.
46:34
You can register for it at the link
46:35
provided in the chat and follow us on social
46:37
media for updates on future case reviews.
46:40
Thanks again for learning with
46:41
us and we will see you soon.
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