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This course will be retired on Oct. 29, 2026.

An updated version of this course will replace this one on Oct. 29, 2026. Nothing changes for you. You can keep working on this course as usual, and you'll earn CME credit whether you finish before or after that date. If you have questions, see our FAQ.

White Matter Disease

Content Reviewed: December 4, 2021

Mastery Series
Preview Course

4 CME

30 DICOM Case Files

47 Videos

4 hr. 2 min. of video

Course Description

Dr. Yousem is back with his most extensive course to date; MRI Mastery Series: White Matter Disease.

With a variety of pathologies and a multitude of presentations, keeping the demyelinating disorders differentiated is challenging at the best of times. Dr. Yousem introduces this series with a look at the anatomy involved in these processes as well as a discussion on imaging technique. We then take a deep dive into case review covering nearly 30 cases.

Some of the diagnoses covered in this course include:

  • Multiple Sclerosis
  • Splenium Demyelination
  • Immune Reconstitution Inflammatory Syndrome
  • Acute Disseminated Encephalomyelitis
  • CADASIL
  • Adrenoleukodystrophy
  • and more…..

Dr. Yousem introduces this series with a look at the anatomy involved in these processes as well as a discussion on imaging technique. We then take a deep dive into case review covering nearly 30 cases.

Faculty

David M Yousem, MD, MBA

Professor of Radiology, Vice Chairman and Associate Dean

Johns Hopkins University

Introduction to Demyelinating Disease

1 m

Imaging Techniques For Demyelinating Disorders

10 m

Research Pulsing Sequences

6 m

The Anatomy of Demyelinating Disease

6 m

ADC Positive Multiple Sclerosis

16 m

ADC Negative Multiple Sclerosis

9 m

Non-enhancing Multiple Sclerosis

6 m

ADC Positive Multiple Sclerosis, Optic Neuritis

6 m

Criteria for Diagnosing Multiple Sclerosis

6 m

MS Plaques

8 m

Expanded Disability Status Scale

4 m

Tumefactive Demyelinating Lesion Summary

3 m

Tumefactive Demyelinating Lesion Vs. Astrocytoma

3 m

Tumefactive Demyelinating Lesion

2 m

Clinically Isolated Syndrome

7 m

Optic Neuritis as an Early Sign of Multiple Sclerosis

5 m

Optic Neuritis Review

6 m

Neuromyelitis Optica Spectrum Disorder – Summary

8 m

Monophasic Neuromyelitis Optica Spectrum Disorder

4 m

Neuromyelitis Optica Spectrum Disorder

6 m

ADEM Summary

5 m

Acute Disseminated Encephalomyelitis

3 m

Suspected Infarct, ADEM

4 m

Progressive Multifocal Leukoencephalopathy Summary

3 m

Progressive Multifocal Leukoencephalopathy

2 m

PML in Autoimmune Deficient Patient

7 m

Immune Reconstitution Inflammatory Syndrome

3 m

COVID Leukoencephalopathy

3 m

Osmotic Demyelination

4 m

Osmotic Demyelination Summary

6 m

Focal Splenium Demyelination

3 m

Splenium Demyelination Due to Anti-epileptic Drug Withdrawal

4 m

Splenium Demyelination Summary

5 m

Vascular Etiologies of White Matter Lesion

11 m

CADASIL Disease

3 m

CADASIL, Hypertensive Hemorrhage

4 m

Binswanger Disease

4 m

Posterior Reversible Encephalopathy Syndrome Summary

7 m

PRES, Patient on Cancer Medication

3 m

Resolved PRES

2 m

Dysmyelinating Disease Summary

12 m

Metachromatic Leukodystrophy

4 m

Canavan's Disease vs. Alexander Disease

2 m

Adrenoleukodystrophy

3 m

Leukoencephalopathy with Cysts and Calcification

3 m

Idiopathic Acquired Transverse Myelitis

6 m

Demyelination – Take Home Messages

5 m

Course Evaluation